2nd International Symposium on Frontiers in Molecular Science

Non-Coding RNAs & Epigenetics in Cancer

 

2nd International Symposium on Frontiers in Molecular Science Non-Coding RNAs and Epigenetics in Cancer logo

21–23 June 2017

Biocenter, University of Basel, Basel, Switzerland

Announcement: Final Deadline for Early Registration Fees 31 March 2017

An international scientific conference organized by the MDPI journals International Journal of Molecular Sciences and Non-Coding RNA

One of the most unexpected and fascinating discoveries in oncology over the past decade has been the interplay between abnormalities in protein-coding genes and non-coding RNAs (ncRNAs), which are causally involved in cancer initiation, progression, and dissemination. Although, to date, the most studied non-coding RNAs (ncRNAs) are miRNAs, the importance of long non-coding RNAs (lncRNAs) is increasingly being recognized. At the conference, entitled “Non-Coding RNAs and Epigenetics in Cancer”, leaders in the field will present the roles of miRNAs and lncRNAs in cancer, with a focus on the recently identified novel mechanisms of action, and discuss the current strategies in designing ncRNA-targeting therapeutics, as well as the associated challenges. We hope to see you all, young in spirit and mind, in the new Eldorado of Science topics in biomedical sciences!

The Non-Coding RNAs and Epigenetics in Cancer will be held in Basel, Switzerland, from 21st to 23rd of June 2017. It will comprise five plenary sessions to highlight the most exciting developments and the latest breakthroughs in oncology.

If you are interested in participating in this conference, and in presenting a poster, or in being selected for a short talk, please register and get in touch with the conference secretariat. The program of the conference is being assembled and will be fully available by March 2017.

For more details and to register: http://sciforum.net/conference/ncRNA-Cancer

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RNAMEDICINE 2017 Symposium

by Christoph on March 24, 2017

in Conferences

RNAMEDICINE 2017

RNA MEDICINE 2017 conference Boston

The third annual day-long iRM (Institute for RNA Medicine – BIDMC Cancer Center/Harvard Medical School) symposium will be held Thursday April 27, 2017, at the Joseph B. Martin Conference Center at Harvard Medical School in Boston. Registration is open!

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New Nature Reviews Drug Discovery publication in the Series “RNA-based therapies”:

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

Summary of the key steps in the development of miRNA therapeutics.Abstract: In just over two decades since the discovery of the first microRNA (miRNA), the field of miRNA biology has expanded considerably. Insights into the roles of miRNAs in development and disease, particularly in cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches. Functional studies have confirmed that miRNA dysregulation is causal in many cases of cancer, with miRNAs acting as tumour suppressors or oncogenes (oncomiRs), and miRNA mimics and molecules targeted at miRNAs (antimiRs) have shown promise in preclinical development. Several miRNA-targeted therapeutics have reached clinical development, including a mimic of the tumour suppressor miRNA miR-34, which reached phase I clinical trials for treating cancer, and antimiRs targeted at miR-122, which reached phase II trials for treating hepatitis. In this article, we describe recent advances in our understanding of miRNAs in cancer and in other diseases and provide an overview of current miRNA therapeutics in the clinic. The authors also discuss the challenge of identifying the most efficacious therapeutic candidates and provide a perspective on achieving safe and targeted delivery of miRNA therapeutics.

Rupaimoole R, Slack FJ.
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017 Mar;16(3):203-222.
doi: 10.1038/nrd.2016.246. Review. PubMed PMID: 28209991.

Full article: http://www.nature.com/nrd/journal/v16/n3/full/nrd.2016.246.html

 

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Indrani Das of New Jersey Wins $250,000 Top Award with microRNA-124a related research.

Forty Finalists From Across U.S. Take Home More Than $1.8 Million inNation’s Oldest and Most Prestigious High School Science and Mathematics Competition

 

WASHINGTON, March 14, 2017 /PRNewswire-USNewswire/ — Society for Science & the Public and Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) announced that Indrani Das, 17, of Oradell, New Jersey, won the top award in the Regeneron Science Talent Search, the nation’s oldest and most prestigious science and math competition. Forty finalists, including Indrani, were honored tonight at the annual Regeneron Science Talent Search Awards Gala for their research projects demonstrating exceptional scientific and mathematical ability, taking home more than $1.8 million in awards provided by Regeneron.

Regeneron Science Talent Search Winners 2017 Washington, D.C., March 14, 2017-Indrani Das, 17, of Oradell, New Jersey, wins top prize and $250,000 in Regeneron Science Talent Search, founded and produced by Society for Science & the Public.

 

Indrani Das, 17, of Oradell, New Jersey, won the top award of $250,000 for her study of a possible approach to treating the death of neurons due to brain injury or neurodegenerative disease. A contributor to neuron death is astrogliosis, a condition that occurs when cells called astrocytes react to injury by growing, dividing and reducing their uptake of glutamate, which in excess is toxic to neurons. In a laboratory model, she showed that exosomes isolated from astrocytes transfected with microRNA-124a both improved astrocyte uptake of glutamate and increased neuron survival. Indrani mentors younger researchers and tutors math in addition to playing the piccolo trumpet in a four-person jazz ensemble.

Second place honors and $175,000 went to Aaron Yeiser, 18, of Schwenksville, Pennsylvania, for his development of a new mathematical method for solving partial differential equations on complicated geometries. Partial differential equations are ubiquitous in science and engineering and are currently solved using computers. He developed a more efficient way to do this and [click to continue…]

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The UEA small RNA Workbench is a suite of tools for analyzing micro RNA and other small RNA data from High-Throughput Sequencing devices.  For a quick overview of what the UEA sRNA Workbench can do for you, and which tool you should select for the task, please visit this page.

Latest release is version 4.2 alpha which is released as java binaries only to streamline the release process until the software moves into the stable release stage of its lifecycle.

Download 4.2 alpha

Changes include:

General

  1. All linux binaries are now compiled as 64bit removing the need to install the 32bit libraries prior to running the software
  2. Bug fixes and stability improvements

miRCat 1 (Version 3.2)

  1. Fixed the show genome browser view

RNA Annotation

  1. Fixed the issues with hairpin sequences not rendering

VisSR

  1. Fixed the issues with the VisSR tool not having required resources included within the most recent build

Database

  1. Chromosome headers can now be much longer than in previous versions (very long chromosome headers such as those found in scaffolded files caused the software to crash)

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Call for Papers: Special Issue – MicroRNA Regulation 2017

June 22, 2016

The International Journal of Molecular Sciences (Impact Factor3.257 (2015); 5-Year Impact Factor: 3.213 (2015)) is working on a Special Issue ” MicroRNA Regulation 2017” and is calling for submissions. For the letter of the special issue editor and manuscript submission details please see: http://www.mdpi.com/journal/ijms/special_issues/miRNA_regulation_2017 CFP dead line: 31 January 2017    

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NYAS miRNA Symposium: A Gene Silencing Mechanism with Therapeutic Implications

June 21, 2016

The Biochemical Pharmacology Discussion Group at the New York Academy of Sciences is presenting  a miRNA Symposium with a great speaker line-up: EVENT:  MicroRNAs: A Gene Silencing Mechanism with Therapeutic Implications WHEN: July 13, 2016  from 9am – 5:00 pm WHERE: The New York Academy of Sciences Conference Center in NYC 7 World Trade Center […]

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Webinar: Plasma miRNAs as potential early biomarkers for acute cardiac injury

June 14, 2016

And a second webinar this week presented by abcam: Time: Thursday, June 16, 2016 3pm-4pm CET / 2pm-3pm GMT / 9am-10am EST Webinar Overview: Drug‑induced cardiac injury (DICI) detection remains a major safety issue in drug development. While circulating microRNAs (miRs) have emerged as promising translational biomarkers, novel early detection biomarkers of cardiotoxicity are needed […]

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Upcoming abcam Webinar: Novel use of extracellular vesicles in the search for biomarkers

June 14, 2016

Time: Wednesday, June 15, 2016 3pm-4pm CET / 2pm-3pm GMT / 9am-10am EST Summary: There are many different types of extracellular vesicles (EVs). Different subpopulations of exosomes, microvesicles and apoptotic bodies have been found to vary in size, composition and intracellular origin. Within the last decade, cell-secreted EVs have been isolated from most of the […]

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Bioinformatics Resources for MicroRNA Discovery

February 9, 2016

Biomarker identification is often associated with the diagnosis and evaluation of various diseases. Recently, the role of microRNA (miRNA) has been implicated in the development of diseases, particularly cancer. With the advent of next-generation RNA sequencing, the amount of data on miRNA has increased tremendously in the last decade, requiring new bioinformatics approaches for processing […]

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