Study Sheds Light on Possible Therapeutic Approach for Neurodegenerative Disease
CINCINNATI, March 27, 2017 /PRNewswire-USNewswire/ — Scientists partially re-insulated ravaged nerves in mouse models of multiple sclerosis (MS) and restored limb mobility by treating the animals with a small non-coding RNA called a microRNA.
In a study published online March 27 in Developmental Cell, researchers at Cincinnati Children’s Hospital Medical Center report that treatment with a microRNA called miR-219 restarted production of a substance called myelin in nerves of the central nervous system. Myelin forms a protective sheath around nerves, allowing them to efficiently transmit electrical impulses that stimulate movement.
Study authors administered miR-219 into the spinal columns and cerebrospinal fluid of mice with nerve coatings damaged by a chemical called lysolecithin or by autoimmune encephalomyelitis induced in the animals, which is used to model MS. Treatment with miR-219 reinvigorated the function of damaged cells called oligodendrocytes that produce myelin, which allowed the substance to reform and reinsulate nerves.
“We show that miR-219 targets multiple processes that inhibit myelin formation after nerve injury by the disease process, and that treatment with this microRNA partially restores myelination and limb function,” said Q. Richard Lu, PhD, lead investigator and scientific director of the Brain Tumor Center at Cincinnati Children’s. “It is conceivable that augmenting miR-219 treatment with other blockers of myelin regrowth may provide a multipoint treatment strategy for people with demyelinating diseases like MS.”
The authors stress that because their study was conducted in [click to continue…]
Deadline for manuscript submissions: 30 April 2017
Non-coding RNA is still accepting submissions for a Special Issue on Non Coding RNA methods. This Special Issue is co guest-edited by Dr. Piero Carninci from the RIKEN Center for Life Science Technologies in Japan and Dr. Florent Hubé from the National Center for Scientific Research (CNRS) in Paris. Accepted papers are published online immediately after copy editing. Non-Coding RNA is an Open Access journal.
ncRNA is a rapidly growing field in which new research methods are continuously appearing. With this Special Issue, the editors aim to collect a selection of articles on newly developed techniques of special interest for researchers in the ncRNA field.
Considered will be manuscripts that report on new experimental methods , as well as reviews of exceptional interest that focus on newly developed techniques for ncRNA research that include:
- ncRNA analysis programs
- ncRNA Chromatography methods
- ncRNA structure analysis
- ncRNA function analysis
- ncRNA by high-throughput screening
- ncRNA Database/Annotation
- ncRNA imaging
- methods to detect the interactome of RNA (with proteins, with chromatin, etc.)
Dr. Piero Carninci
Dr. Florent Hubé
Please use the online submission system and indicate in your cover letter that you would like to have your manuscript considered for the Special Issue “Non Coding RNA methods”. If you would like to enquire [click to continue…]
March 28th 2017:
Demonstration of Qlucore Omics Explorer, the bioinformatics software for scientists, biologists looking for a user-friendly analysis software for instant visualization and exploration of data.
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2nd International Symposium on Frontiers in Molecular Science
Non-Coding RNAs & Epigenetics in Cancer
21–23 June 2017
Biocenter, University of Basel, Basel, Switzerland
Announcement: Final Deadline for Early Registration Fees 31 March 2017
An international scientific conference organized by the MDPI journals International Journal of Molecular Sciences and Non-Coding RNA
One of the most unexpected and fascinating discoveries in oncology over the past decade has been the interplay between abnormalities in protein-coding genes and non-coding RNAs (ncRNAs), which are causally involved in cancer initiation, progression, and dissemination. Although, to date, the most studied non-coding RNAs (ncRNAs) are miRNAs, the importance of long non-coding RNAs (lncRNAs) is increasingly being recognized. At the conference, entitled “Non-Coding RNAs and Epigenetics in Cancer”, leaders in the field will present the roles of miRNAs and lncRNAs in cancer, with a focus on the recently identified novel mechanisms of action, and discuss the current strategies in designing ncRNA-targeting therapeutics, as well as the associated challenges. We hope to see you all, young in spirit and mind, in the new Eldorado of Science topics in biomedical sciences!
The Non-Coding RNAs and Epigenetics in Cancer will be held in Basel, Switzerland, from 21st to 23rd of June 2017. It will comprise five plenary sessions to highlight the most exciting developments and the latest breakthroughs in oncology.
If you are interested in participating in this conference, and in presenting a poster, or in being selected for a short talk, please register and get in touch with the conference secretariat. The program of the conference is being assembled and will be fully available by March 2017.
For more details and to register: http://sciforum.net/conference/ncRNA-Cancer
The third annual day-long iRM (Institute for RNA Medicine – BIDMC Cancer Center/Harvard Medical School) symposium will be held Thursday April 27, 2017, at the Joseph B. Martin Conference Center at Harvard Medical School in Boston. Registration is open!