New experimentally demonstrated miRecords content enhances the powerful target prioritization capabilities of IPA’s microRNA Target Filter.
REDWOOD CITY, Calif., Sept. 20, 2011 – Ingenuity® Systems, a leading provider of information and analytics solutions for life science researchers, today announced the addition of new experimentally validated microRNA-mRNA target interactions from miRecords, plus thousands of additional miRNA-mRNA interactions manually curated from additional peer-reviewed literature. The newly added content supplements existing experimentally demonstrated and predicted miRNA targets in IPA, and will be used by IPA’s microRNA Target Filter to help researchers quickly and reliably prioritize miRNA target interactions.
“IPA and its microRNA Target Filter have been very impactful for our research,” stated Arupa Ganguly, Ph.D. Professor of Genetics at the Hospital of the University of Pennsylvania. “We compared gene expression signatures of matched normal retinal tissue and retinoblastoma tumor tissue, and then used IPA for biological analysis of the data. Using microRNA and mRNA from same tumors, we applied the microRNA Target Filter in combination with the content in IPA. This approach helped us rapidly narrow in on key microRNAs we thought to be involved with tumor progression.”
Today, there is no other software tool on the market that has this powerful combination of microRNA tools and content in one place. IPA allows researchers to examine both predicted and experimentally demonstrated microRNA-mRNA pairings, prioritize targets based on relevant biological context, and visualize the molecular interactions of those target relationships and related biological impacts. This streamlines a workflow that previously took days: researchers can now take lists of over 13,000 potential targets down to just 2 of the most biologically relevant in a matter of minutes.
About Ingenuity® Systems
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