Researchers at the University of Texas Southwestern Medical Center, Dallas have identified miR-206 as a modifier of amyotrophic lateral sclerosis (ALS) pathogenesis and define a role for a microRNA (miR-206) in reinnervating the neuromuscular junction after injury and improving survival in a mouse model of the disease. The findings provide insight into the molecular basis of neuromuscular junction plasticity and also into determinants of rates of disease progression in motor neuron disease and suggest opportunities for intervention through the modulation of miR-206.
Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN. (2009) MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 326(5959), 1549-54 [abstract]
Additionally, a perspective on these important findings was published in the same issue of Science.
Brown, RH. (2009) A Reinnervating MicroRNA. Science 326(5959), 1494-95. [abstract]