- Determining whether lung cancer has spread is critical for identifying the most effective therapy.
- This study found that high levels of microRNA-31 indicate that the tumor has spread and signals a poor prognosis.
- The findings might lead to improved treatment for some people with the most common form of lung cancer.
Meng W, Ye Z, Cui R, Perry J, Dedousi-Huebner V, Huebner A, Wang Y, Li B, Volinia S, Nakanishi H, Kim T, Suh SS, Ayers LW, Ross P, Croce CM, Chakravarti A, Jin VX, Lautenschlaeger T.
Clin Cancer Res. 2013 Sep 12. [Epub ahead of print]
PMID: 23946296 [PubMed – as supplied by publisher]
- MiR-31 expression was four times higher in patients with lymph node metastases compared with those without them.
- miR-31 increases cell migration, invasion and proliferation;
- High miR-31 expression predicted poor survival, while low expression was associated with excellent survival.
– See more at: http://www.cancer.osu.edu/mediaroom/releases/Pages/MicroRNA31-Might-Predict-Lung-Cancer-Spread.aspx#sthash.9v3iTPSq.dpuf