microRNA Abstracts – AACR Meeting 2010

by Chris on April 12, 2010

in Conferences

Presentation  Authors Session
Mon, Apr 19, 2:00 – 5:00 PM
2080/1 – miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma
Mayuko Furuta1, Ken-ichi Kozaki2, Shinji Tanaka2, Shigeki Arii2, Issei Imoto2, Johji Inazawa1. 1Tokyo Medical and Dental University & GCOE program for IHMSTBD, Tokyo, Japan; 2Tokyo Medical and Dental University, Tokyo, Japan Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2020/1 – MiR-210 modulates the hypoxic response in endothelial and ovarian cancer cells
Indira V. Subramanian, Goutam Ghosh, Hemant Joshi, Yan Zheng, Alexey Benyumov, Sundaram Ramakrishnan. Univ. of Minnesota, Minneapolis, MN Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Wed, Apr 21, 8:00 – 11:00 AM
5698/1 – MicroRNA-31 acts as an oncomir in lung cancer by repressing specific tumor suppressors
Xi Liu1, Lorenzo F. Sempere1, Haoxu Ouyang1, Vincent A. Memoli1, Angeline S. Andrew1, Yue Luo1, Eugene Demidenko1, Murray Korc1, Wei Shi1, Meir Preis1, Konstantin H. Dragnev1, Hua Liu1, James DiRenzo1, Mads Bak2, Sakari Kauppinen3, Sarah J. Freemantle1, Ethan Dmitrovsky1. 1Dartmouth Medical School, Hanover, NH; 2University of Copenhagen, Copenhagen, Denmark; 3Copenhagen Institute of Technology, Aalborg University, Copenhagen, Denmark Poster Session
PO.PR01.04. Preclinical Studies in Prevention Research: New Biomarkers, Agents, and Mechanisms
Wed, Apr 21, 8:00 – 11:00 AM
Tue, Apr 20, 9:00 AM – 12:00 PM
3025/1 – Detection of prostatic fluid micro-RNA species associated with prostate cancer
Holly B. Lewis, Raymond S. Lance, Richard R. Drake, Aurora E. Kerscher. Eastern Virginia Medical School, Norfolk, VA Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4031/1 – Elevated expression of microRNAs in pancreatic carcinomas is correlated with poor prognosis
Thomas Greither1, Philipp Grochola2, Andrej Udelnow3, Christine Lautenschläger4, Alexander W. Eckert1, Peter Würl3, Helge W. Taubert1. 1Department of Oral and Maxillofacial Plastic Surgery, Martin-Luther-Univ. Halle-Wittenberg, Halle, Germany; 2The Ludwig Institute for Cancer Research, Oxford, United Kingdom; 3Department of General, Visceral and Transplantation Surgery, The University Hospital of Ulm, Ulm, Germany; 4Institute of Medical Biometry and Informatics, Martin-Luther-Univ. Halle-Wittenberg, Halle, Germany Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2050/1 – MicroRNA-124a: A master regulator of glioblastoma migration
Kerrie L. McDonald1, Adam Fowler1, Daniel Thomson1, Keith Giles2, Peter Leedman2, Bruce G. Robinson3. 1Kolling Institute of Medical Research, St Leonards, Australia; 2Western Australia Institute of Medical Research, Perth, Australia; 3University of Sydney, Sydney, Australia Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
2995/1 – MicroRNA expression and outcome of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer: International Adjuvant Lung Cancer Trial Biologic Program (IALT-Bio)
Johannes Voortman1, Akiteru Goto2, Jean Mendiboure3, Jane J. Sohn2, Aaron J. Schetter2, Ariane Dunant3, Mohamed Khan2, Trung C. Pham1, Iacopo Petrini1, Alan Lee1, Pierre Hainaut4, Jean-Pierre Pignon3, Elisabeth Brambilla5, Helmut H. Popper6, Martin Filipits7, Curtis C. Harris2, Giuseppe Giaccone1. 1Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; 2Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD; 3Biostatistics and Epidemiology Unit and Department of Medicine, Institut Gustave Roussy, Villejuif, France; 4International Agency for Research on Cancer, Lyon, France; 5Institut National de la Santé et de la Recherche Médicale, Université Joseph Fourier, Department of Pathology, Grenoble Hospital, Grenoble, France; 6Institute of Pathology, Medical University of Graz, Graz, Austria; 7Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Wed, Apr 21, 8:00 – 11:00 AM
5699/2 – Obesity-induced colon tumorigenesis is associated with increased cytokine production and alterations in microRNA expression
Susan E. Olivo-Marston1, Aaron J. Schetter2, Mohammed A. Khan2, Stephen D. Hursting3, Rami S. Maarouf4, Curtis C. Harris2, Jackie Lavigne2. 1The Ohio State University, Columbus, OH; 2The National Cancer Institute, Bethesda, MD; 3The University of Texas-Austin, Austin, TX; 4The University of Virginia, Charlottesville, VA Poster Session
PO.PR01.04. Preclinical Studies in Prevention Research: New Biomarkers, Agents, and Mechanisms
Wed, Apr 21, 8:00 – 11:00 AM
Sun, Apr 18, 2:00 – 5:00 PM
172/2 – A role for the demethylation of microRNA-496 in MBD2-mediated repression
Sebastian G. Alvarado, Stephen D. Andrews, Flora Chik, Moshe Szyf. McGill, Montreal, QC, Canada Poster Session
PO.CB06.05. DNA Methylation 2
Sun, Apr 18, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2051/2 – DNA (cytosine-5-)-methyltransferases 3A (DNMT3A) is a direct target of miR-194 in breast cancer
Xiao-Feng Le, Riccardo Spizzo, Maggie Mao, Yun Wu, George A. Calin, Robert C. Bast, Jr.. UT M.D. Anderson Cancer Ctr., Houston, TX Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3026/2 – miR-203 and miR-205 expression profiles are predictive of high grade non-invasive urothelial carcinoma progression
Kimberly M. Rieger-Christ, Sheaumei Tsai, Sara M. Lenherr, Cara B. Cimmino, Jason R. Gee, John A. Libertino, Ian C. Summerhayes. Lahey Clinic, Burlington, MA Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4591/2 – Estrogen receptor beta controls a wide variety of functions in breast cancer cells
Maria Cekanova1, Jirayus Woraratphoka1, Mugdha Sukhthankar1, S. Dharmawardhana2, Nalin Siriwardana1, Naima Moustaid-Moussa1, Anders Strom3, Seung J. Baek1, Q. Wong4, M. Zou4, Robert Donnell1, Jay Wimalasena1. 1University of Tennesse, Knoxville, TN; 2University of Puerto Rico Medical Sciences, San Juan, Puerto Rico; 3University of Houston, Houston, TX; 4University of Oklahoma, Medical Center, Oklahoma City, OK Poster Session
PO.EN01.01. Regulation of Estrogen Receptor-Positive and -Negative Breast Cancer
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2021/2 – MicroRNA affinity assay
Miao Shi, Weiguo Han, Simon Spivack. Albert Einstein College of Medicine, Bronx, NY Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2081/2 – Frequent silencing of tumor suppressive MicroRNA-34b/c by aberrant methylation in malignant mesothelioma
Takafumi Kubo1, Shinichi Toyooka1, Kazunori Tsukuda1, Hiroaki Asano1, Masakiyo Sakaguchi2, Junichi Soh1, Tsuyoshi Ueno1, Hiromasa Yamamoto1, Masaomi Yamane1, Takahiro Oto1, Yasutomo Nasu3, Hideki Matsui4, Nam ho Huh2, Shinichro Miyoshi1. 1Dept. of Cancer and Thoracic Surgery, Okayama Univ. Grad. School of Med, Dent. & Pharm.Sci., Okayama, Japan; 2Dept. of Cell Biology, Okayama Univ. Grad. School of Med, Dent. & Pharm.Sci., Okayama, Japan; 3Dept. of Urology, Okayama Univ. Grad. School of Med, Dent. & Pharm.Sci., Okayama, Japan; 4Dept. of physiology, Okayama Univ. Grad. School of Med, Dent. & Pharm.Sci., Okayama, Japan Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4032/2 – Elevated level of let-7a and mir-30c microRNAs in human prostate cancer
Bhagavathi A. Narayanan1, Hye Na Kim1, Arul M. Chinnaiyan2, Jonathan Melamed3, Narayanan K. Narayanan1. 1New York Univ. School of Medicine, Tuxedo, NY; 2University of Michigan, Ann Arbor, MI; 3New York Univ. School of Medicine, New York, NY Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
2996/2 – Overexpression of potential oncogenic microRNAs defines a new molecular subclass of hepatocellular carcinoma
Sara Toffanin1, Yujin Hoshida2, Anja Lachenmayer1, Laia Cabellos1, Jun Lu2, Augusto Villanueva3, Beatriz Minguez1, Radoslav Savic1, Derek Y. Chiang2, Sasan Roayaie1, Jordi Bruix3, Myron E. Schwartz1, Vincenzo Mazzaferro4, Samuel Waxman1, Scott L. Friedman1, Todd R. Golub2, Josep M. Llovet1. 1Mount Sinai Liver Cancer Program, Division of Liver Diseases, Hem/Onc and Surgical Oncology, Mount Sinai School of Medicine, New York, NY; 2Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA; 3Barcelona-Clinic Liver Cancer Group, Liver Unit, CIBERehd, Hospital Clínic, IDIBAPS, Barcelona, Spain; 4National Cancer Institute, IRCSS Foundation, Milan, Italy Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2545/2 – Regulation of NF-YB by miR-485-3p affects TopoisomeraseIIα expression
Cheng-Fen Chen, William T. Beck, Xiaolong He. Univ. of Illinois, Chicago, IL Poster Session
PO.ET04.03. Mechanisms of Resistance 3: Chemotherapeutics
Mon, Apr 19, 2:00 – 5:00 PM
Sun, Apr 18, 2:00 – 5:00 PM
814/3 – A systemic miRNA signature predictive of early breast cancer
Helen M. Heneghan, Nicola Miller, Ronan Kelly, Mary Nugent, Michael J. Kerin. National University of Ireland Galway, Galway, Ireland Poster Session
PO.CL01.03. Molecular Diagnostics and Therapeutic Targets 1
Sun, Apr 18, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
2998/4 – MicroRNA expression signatures in human ovarian tumor progression
Jian-jun Zhao1, William Kong1, Jianhong Lin1, Jennifer Wey1, Hua Yang1, domenico coppola1, Yi-Chun Lee2, Robert Wenham1, Johnathan Lancaster1, Thomas Sellers1, Jin Q. Cheng1. 1H. Lee Moffitt Cancer Ctr. & Res. Inst., Tampa, FL; 2Gynecological Oncology, Obstetrics & Gynecology, Brooklyn, NY Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3027/3 – Plasma microRNA as a potential marker for breast cancer detection
Enders K.O. Ng1, Candy Leung1, Stephanie Au1, Aaron Chan1, Chris Wong2, Edmond Ma2, Roberta Pang1, Daniel Chua1, KM Chu1, WL Law1, Ronnie TP Poon1, Ava Kwong1. 1The University of Hong Kong, Pokfulam, Hong Kong; 2Hong Kong Sanatorium & Hospital, Hong Kong Island, Hong Kong Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4033/3 – MiR-21 upregulation in breast cancer cells leads to PTEN loss and Herceptin resistance
Sumaiyah K. Rehman, Wen-Chien Huang, Dihua Yu. UT M.D. Anderson Cancer Ctr., Houston, TX Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2082/3 – The microRNA-101 regulates the expression of EP4 receptor in colon cancers
Anupama Chandramouli, Lenka Stankova, Jennifer M. Davenport, Renee Shanas, Jenae M. Owens, Bonnie J. LaFleur, Achyut K. Bhattacharyya, Mark A. Nelson. Univ. of Arizona, Tucson, AZ Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2052/3 – MicroRNA-101 promotes apoptosis and suppresses proliferation in esophageal squamous cell carcinoma by repressing the polycomb group protein EZH2
Yukiharu Hiyoshi, Hidenobu Kamohara, Junji Kurashige, Kouichi Kinoshita, Naoko Hayashi, Masayuki Watanabe, Hideo Baba. Kumamoto University, Kumamoto, Japan Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Sun, Apr 18, 2:00 – 5:00 PM
815/4 – Relationship between altered expression levels of MIR21, MIR143, MIR145, and MIR205 and clinicopathologic features of esophageal squamous cell carcinoma(ESCC)
Hiroshi Makino, Eiji Ucida, Ichiro Akagi, Masao Miyashita, Tsutomu Nomura, Nobutoshi Hagiwara, Osamu Ishibashi, Toshihiro Takizawa. Nippon Medical School, Tokyo, Japan Poster Session
PO.CL01.03. Molecular Diagnostics and Therapeutic Targets 1
Sun, Apr 18, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2350/4 – MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
Mohit Sachdeva, Yin Yuan Mo. SIUMED, Springfield, IL Poster Session
PO.TB04.04. Mechanisms of Tumor Metastasis 1
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2083/4 – microRNA-616 induces androgen-independent growth of prostate cancer cells through suppression of TFPI-2 expression
Stephanie Ma, Yuen Piu Chan, Pak Shing Kwan, Kwan Ho Tang, Juergen Vielkind, Xin Yuan Guan, Kwok Wah Chan. Univ. of Hong Kong, Pokfulam, Hong Kong Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4034/4 – Disease- and race-related differences in microRNAs and zinc transporter 1 in human prostate tissue
Nicoleta C. Arva1, Avani Vaishnav1, Ekaterina Khramtsova1, Omar Bagasra2, Andre Kajdacsy-Balla1, Larisa Nonn1. 1University of Illinois at Chicago, Chicago, IL; 2Claflin University, Orangeburg, SC Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 10:40 – 10:55 AM
1946 – Identification of miRNAs that contribute to melanoma brain metastasis
Avital Gaziel1, Silvia Menendez1, Miguel F. Segura1, Jan Zakrzewski2, Amy Rose2, Robert S. Kerbel3, Farbod Darvishian2, Dalia Cohen4, Iman Osman2, Eva Hernando1. 1New York University, School of Medicine,Department of Pathology, New York, NY; 2New York University, School of Medicine,Department of Dermatology, New York, NY; 3Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 4Rosetta Genomics, Inc., Rehovot, Israel Minisymposium
MS.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 1
Mon, Apr 19, 10:30 AM – 1:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2008/4 – An investigation of the regulation of cellular processes in glioblastoma multiforme via integrated analysis of paired microRNA and gene expression profiles
Antti Ylipaa1, Matti Nykter1, Ilya Shmulevich2, Wei Zhang3. 1Tampere University of Technology, Tampere, Finland; 2Institute for Systems Biology, Seattle, WA; 3The University of Texas M. D. Anderson Cancer Center, Houston, TX Poster Session
PO.CB14.01. Cancer Systems Biology and Integrative Analysis
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2053/4 – Regulation of microRNA-10b by CCN5/WISP-2 in breast cancer: A novel mechanism of CCN5/WISP-2 mediated suppression of invasive front
Inamul Haque, Snigdha Banerjee, Smita Mehta, Teresa A. Phillips, Gopal Dhar, Suman Kambhampati, Sushanta K. Banerjee. VA Medical Center, Kansas City, KS Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2023/4 – Potential importance of micro-RNA-193b in human head and neck squamous cell carcinoma
Michelle Lenarduzzi, Angela Hui, Nehad Alajez, Christine How, Fei Fei Liu. Ontario Cancer Institute, Toronto, ON, Canada Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
2999/5 – Assessment of microRNA expression in two-dimensional histopathological fields of breast cancer
Alex M. Rosenberg1, Christine K. Zoon1, Elizabeth S. Clark1, Michael D. Armani1, Benjamin Shapiro2, Elisabeth Smela2, Jeffrey C. Hanson1, Jaime Rodriguez-Canales1, Michael R. Emmert-Buck1, Michael A. Tangrea1. 1National Cancer Institute, Bethesda, MD; 2Univeristy of Maryland, College Park, MD Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3029/5 – A KRAS microRNA binding site polymorphism as a novel biomarker of risk in triple negative breast cancer
Trupti S. Paranjape1, Helen Heneghan2, Cory Pelletier1, Aaron Hoffman1, Michael J. Kerin2, Lyndsay Harris1, Yong Zhu1, Nicola Miller2, Daniel Zelterman1, David Tuck1, Frank Slack1, Joanne Weidhaas1. 1Yale Univ., New Haven, CT; 2Clinical Science Institute, NUI, Galaway, Ireland Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3030/6 – An exosome isolation system for serum-based cancer biomarker discovery
Fangting Wu, Travis J. Antes. System Biosciences (SBI), Mountain View, CA Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2293/5 – ZEB1 and ZEB2 promote EMT and invasion in esophageal squamous cell carcinoma
Seiji Naganuma1, Shinya Ohashi2, Sotai Kimura1, Mitsuteru Natsuizaka2, Phyllis Gimotty3, Andres J. Klein-Szanto4, Hiroshi Itoh1, Hiroshi Nakagawa2. 1Division of Tumor Pathology, Department of Pathological Sciences, School of Medicine, University of Fukui, Fukui, Japan; 2Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; 3Univ. of Pennsylvania, Philadelphia, PA; 4Fox Chase Cancer Center, Philadelphia, PA Poster Session
PO.TB04.02. Epithelial-Mesenchymal Transition
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4035/5 – MicroRNA-221 levels correlate with aggressive and clinically recurrent prostate cancers
Aida Gordanpour1, Aleksandra Stanimirovic2, Robert Nam2, Carlos Moreno3, Brian Leyland-Jones3, Linda Sugar4, Arun Seth1. 1Department of Pathology and Laboratory Medicine, University of Toronto, Toronto, ON, Canada; 2Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada; 3Hematology and Medical Oncology, Emory University, Atlanta, GA; 4Department of Pathology, Sunnybrook Health Science Centre, University of Toronto, Toronto, ON, Canada Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3000/6 – MicroRNA-21 as a biomarker for benefit from adjuvant therapy in resectable pancreatic adenocarcinoma
Johannes Voortman1, Jin-Hyeok Hwang1, Elisa Giovannetti2, Seth M. Steinberg3, Yong-Tae Kim4, Niccola Funel5, Joo Kyung Park4, Min A. Kim6, Gyeong Hoon Kang6, Sun-Whe Kim7, Marco Del Chiaro5, Godefridus J. Peters2, Giuseppe Giaccone1. 1Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; 2Dept. of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands; 3Biostatistic and Data Management Section, National Cancer Institute, National Institutes of Health, Rockville, MD; 4Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of; 5Divisione di Chirurgia Generale e dei Trapianti dell’Uremico e del Diabetico, Hospital of Pisa, Pisa, Italy; 6Dept of Pathology, Seoul National University College of Medicine, Seoul, Korea, Republic of; 7Dept of Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 10:55 – 11:10 AM
1947 – Identification of microRNAs that regulate DNA damage response
Yemin Wang, Toshiyasu Taniguchi. Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA Minisymposium
MS.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 1
Mon, Apr 19, 10:30 AM – 1:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2054/5 – A microRNA hypothesis for the precursor lesions of ovarian cancer
Kuan-Chun Huang1, Yilan Zhou1, Kathleen Hasselblatt1, Junzheng Yang1, Pui-Wah Choi2, Wing-Ping Fong2, Colleen Felmate1, Michael G. Muto1, Nelly Auersperg3, Christopher P. Crum1, Ross S. Berkowitz1, Shu-Wing Ng1. 1Brigham and Women’s Hospital, Boston, MA; 2The Chinese University of Hong Kong, Hong Kong, Hong Kong; 3University of British Columbia, Vancouver, BC, Canada Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2024/5 – Over-expression of miR-106b in metastatic hepatocellular carcinoma using an orthotopic metastasis animal model.
Wing Lung Yau, Roberta Wen Chi Pang, Terence Kin Wah Lee, Jana Yim Hung Wo, Ronnie Tung Ping Poon. The University of Hong Kong, Hong Kong, Hong Kong Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2723/5 – Circulating microRNA as a biomarker for screening for hepatocellular carcinoma
Kevin Z. Qu, Ke Zhang, Maher Albitar. Quest Diagnostics Nichols Institute, San Juan Capistrano, CA Poster Session
PO.CL13.06. Diagnostic Biomarkers
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2084/5 – Tumor suppressor microRNA miR-34 inhibits human pancreatic cancer stem cells
Wenhua Tang, Qing Ji, Xinbao Hao, Ling Li, DeSano Jeffrey, Eric R. Fearon, Theodore S. Lawrence, Liang Xu. Univ. of Michigan, Ann Arbor, MI Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2085/6 – Mir-30 acts as an anti-metastatic microRNA and is downregulated in non-small cell lung cancer (NSCLC)
Kumarswamy Regalla1, Giridhar Mudduluru1, Paolo Ceppi2, Miroslaw Kozlowski3, Jacek Nikliński3, Heike Allgayer4. 1Medical Faculty Mannheim of University Heidelberg, Mannheim, Germany; 2University of Turin, Turin, Italy; 3Medical University Bialystok, Bialystok, Poland; 4Medical Faculty Mannheim of University Heidelberg and German Cancer Research Center, Heidelberg, Germany Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 11:10 – 11:25 AM
1948 – Pvt1-encoded microRNA miR-1204 in tumorigenesis of human ovarian and breast cancer
Jing Huang1, Eric A. Collisson2, Bill Gibb1, Lakshmi Jakkula1, Steven Martin3, Joe w. Gray1. 1Lawrence Berkeley National Laboratory, Berkeley, CA; 2UCSF Comprehensive Cancer Center, San Francisco, CA; 3University of California at Berkeley, Berkeley, CA Minisymposium
MS.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 1
Mon, Apr 19, 10:30 AM – 1:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4036/6 – The microRNA profile of prostate carcinoma obtained by deep sequencing reveals potential miRNA targets such as myosin VI
Jaroslaw Szczyrba1, Elke Löprich2, Sven Wach2, Volker Jung3, Gerhard Unteregger3, Stephanie Barth1, Rainer Grobholz4, Wolf Wieland5, Robert Stöhr6, Arndt Hartmann6, Bernd Wullich2, Friedrich Grässer1. 1Department of Virology, University of Saarland Medical School, Homburg/Saar, Germany; 2Department of Urology, University Hospital of Erlangen-Nürnberg, Erlangen, Germany; 3Department of Urology, University of Saarland Medical School, Homburg/Saar, Germany; 4Department of Pathology, University of Saarland Medical School, Homburg/Saar, Germany; 5Department of Urology, University Hospital Regensburg, Regensburg, Germany; 6Department of Pathology, University Hospital of Erlangen-Nürnberg, Erlangen, Germany Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Sun, Apr 18, 1:40 – 1:55 PM
3 – OncomiR-155 targets oncogenes HDAC4 and BCL6 in a murine B cell leukemia model: A paradigm shift in the oncogenic mechanisms of microRNAs
Sukhinder K. Sandhu, Stefan Costinean, Reid Neinast, Mark Parthun, Ramiro Garzon, Carlo Croce. The Ohio State Univ., Columbus, OH Minisymposium
MS.CB05.01. Gene Regulation and Cancer
Sun, Apr 18, 1:00 – 3:30 PM
Mon, Apr 19, 2:00 – 5:00 PM
2055/6 – miR-17-3p suppresses tumorigencity of prostate cancer through inhibiting mitochondrial antioxidant enzymes
Yong Xu1, Fang Fang1, Sajni Josson2, Daret K. St. Clair1, William H. St. Clair1. 1Univ. of Kentucky, Lexington, KY; 2UCLA, Los Angeles, CA Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Wed, Apr 21, 8:00 – 11:00 AM
4896/6 – The detection and analysis of epigenetic and genetic changes in ovarian tumor tissue
Matthew Poulin, Jessica Xu, Liying Yan. EpigenDx, Inc., Worcester, MA Poster Session
PO.CB06.04. DNA Methylation 3
Wed, Apr 21, 8:00 – 11:00 AM
Tue, Apr 20, 9:00 AM – 12:00 PM
3031/7 – Screening for plasma micro RNAs as biomarkers for breast cancer detection
Catalin Marian, Ionut Bebu, Danesh Kella, Xin Zhou, Md Islam, Habtom Ressom, Peter Shields, Yun-Ling Zheng. Georgetown Univ. Medical Ctr., Lombardi Cancer Center, Washington, DC Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3558/6 – The natural product silvestrol decreases oncogenic FLT3 and miR-155 levels in FLT3-ITD positive Acute Myeloid Leukemia (AML) cells
Houda Alachkar, Shujun Liu, Sebastian Schwind, Heiko Becker, Klaus H. Metzeler, Christopher Hickey, Jiuxia Pang, Susan P. Whitman, Kenneth K. Chan, Ramiro Garzon, David M. Lucas, Danilo Perrotti, Lai-Chu Wu, Michael R. Grever, A. D. Kinghorn, Guido Marcucci. Ohio State University, Columbus, OH Poster Session
PO.ET06.10. Novel Inhibitors and Mechanisms
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3002/8 – Serum miRNA signatures predict survival of NSCLC
Hu Zhibin1, Xi Chen2, Guangfu Jin1, Ke Zen2, Chen Yu Zhang2, Hongbing Shen1. 1Nanjing Medical University, Nanjing, China; 2Nanjing University, Nanjing, China Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3032/8 – MicroRNA profiling in head and neck cancer
Ya-Ching Lu, Ann-Joy Cheng. Chang Gung University, Tao-Yuan, Taiwan Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2056/7 – MicroRNA-126 inhibits SOX2 expression in gastric cancer cells
Takeshi Otsubo, Yoshimitsu Akiyama, Yutaka Hashimoto, Yasuhito Yuasa. Tokyo Medical and Dental University, Tokyo, Japan Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2026/7 – MicroRNA-214 is a negative regulator of p53
Hua Yang, William Kong, Kendra Williams, Lili He, Jin Q. Cheng. H. Lee Moffitt Cancer Ctr. & Res. Inst., Tampa, FL Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Sun, Apr 18, 2:00 – 5:00 PM
177/7 – MicroRNA expression profiling in non-small cell lung cancer cells treated with 5-aza-2´-deoxycytidine and trichostatin A
Gerwin Heller, Valerie Babinsky, Barbara Ziegler, Christoph C. Zielinski, Sabine Zöchbauer-Müller. Medical University of Vienna; Department of Medicine I, Vienna, Austria Poster Session
PO.CB06.05. DNA Methylation 2
Sun, Apr 18, 2:00 – 5:00 PM
Mon, Apr 19, 11:25 – 11:40 AM
1949 – Positive feedback regulation between EWS-FLI1 and miR-145 in Ewing’s sarcoma
Jozef Ban1, Pieter Mestdagh2, Max Kauer1, Gunhild Jug1, Frank Speleman2, Heinrich Kovar1. 1Children’s Cancer Research Inst., Vienna, Austria; 2Center for Medical Genetics Ghent (CMGG), Ghent University Hospital, Ghent, Belgium Minisymposium
MS.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 1
Mon, Apr 19, 10:30 AM – 1:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2295/7 – Knockdown of ZEB1, a master EMT gene, suppresses anchorage-independent cell growth of lung cancer cells
Mitsuo Sato1, Yoshihiro Takeyama1, Mihoko Horio1, Tetsunari Hase1, Kenya Yoshida1, Harunori Nakashima1, Naozumi Hashimoto1, Yoshitaka Sekido2, Adi F. Gazdar3, John D. Minna3, Masashi Kondo1, Yoshinori Hasegawa1. 1Nagoya Univ. School of Medicine, Nagoya, Japan; 2Aichi Cancer Center Research Institute, Nagoya, Japan; 3Hamon Center for Therapeutic Oncology Research, Dallas, TX Poster Session
PO.TB04.02. Epithelial-Mesenchymal Transition
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4037/7 – Higher Expressions of miR-21, miR-106a, miR-181b, and miR-203 are Associated with Poor Prognosis in Colorectal Cancer Patients
Liselle Bovell1, Venkat R. Katkoori1, Chandrakumar Shanmugam1, Choo H. Lee1, Sreelatha Meleth1, Harvey L. Bumpers2, William E. Grizzle1, Upender Manne1. 1University of Alabama at Birmingham, Birmingham, AL; 2Morehouse School of Medicine, Atlanta, GA Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
1984/7 – A novel logistic regression model for microRNA microarray normalization
Bin Wang1, Paul Howell1, Xiaofeng Wang2, Xuemin Qian1, Kun Huang1, Adam Riker3, Jingfang Ju4, Yaguang Xi1. 1Univ. of South Alabama Mitchell Cancer Inst., Mobile, AL; 2Cleveland Clinic, Cleveland, OH; 3Ochsner Health System, New Orleans, LA; 4Stony Brook University, Stony Brook, NY Poster Session
PO.CB11.01. Cancer Genomics and Bioinformatics 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4038/8 – Identification of microRNAs involved in colorectal cancer progression
Manuela Gariboldi1, Andrea Lampis1, Viktorija Sokolova2, Sara Pizzamiglio1, James F. Reid2, Susanna Zanutto2, Claudia Bertan1, Federica Perrone1, Paolo Verderio1, Ermanno Leo1, Marco Pierotti1. 1Fondazione IRCCS Istituto Nazionale dei Tumori Milano, Milano, Italy; 2FIRC Institute of Molecular Oncology Foundation, Milano, Italy Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 11:40 – 11:55 AM
1950 – Suppression of RISC-independent decoy and RISC-mediated RNA-pairing activities of microRNA-328 is required for maturation-arrest and enhanced survival of blast crisis CML progenitors
Anna M. Eiring1, Jason Harb1, Paolo Neviani1, Joshua J. Oaks1, Shujun Liu1, Riccardo Spizzo2, Sebastian Schwind1, Ramasamy Santhanam1, Christopher Hickey1, Heiko Becker1, Jason C. Chandler1, Raul Andino3, Jorge Cortes2, Peter Hokland, Sr.4, Claudia S. Huettner5, Ravi Bhatia6, Denis C. Roy7, Stephen Liebhaber8, Michael A. Caligiuri1, Guido Marcucci1, Ramiro Garzon1, Carlo M. Croce1, George A. Calin2, Danilo Perrotti1. 1Ohio State Univ. Medical Ctr., Columbus, OH; 2MD Anderson Cancer Center, Houston, TX; 3UCSF, San Francisco, CA; 4University of Aarhus, Aarhus, Denmark; 5Harvard Medical School, DFCC, Boston, MA; 6City of Hope National Medical Ctr, Duarte, CA; 7Maissoneuve-Rosemont Hospital, Montreal, QC, Canada; 8University of Pennsylvania, Philadelphia, PA Minisymposium
MS.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 1
Mon, Apr 19, 10:30 AM – 1:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4088/8 – Effects of exposure to particulate matter on methylation of miRNA genes coding for miR-21 and miR-222
Valeria Motta1, Valentina Bollati1, Barbara Marinelli1, Lifang Hou2, Pietro Apostoli3, Matteo Bonzini4, Francesco Nordio1, Valeria Pegoraro1, Letizia Tarantini1, Joel Schwartz5, Pieralberto Bertazzi1, Andrea Baccarelli1. 1Università degli Studi di Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e, Milan, Italy; 2Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL; 3Department of Experimental and Applied Medicine, Occupational Medicine and Industrial Hygiene, University of Brescia, Brescia, Italy; 4Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy; 5Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA Poster Session
PO.CB13.06. Noncoding RNAs and Epigenetic Control of MicroRNAs
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3033/9 – Profiling of global changes in microRNA levels during adipocyte differentiation by real-time PCR
Thomas Sebastian, Elica Dhundia, Subrahmanyam Yerramilli, Eric Lader. Qiagen Sciences, Germantown, MD Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 3:40 – 3:55 PM
4819 – MicroRNA-21 (miR-21) in pancreatic ductal adenocarcinoma (PDAC): Correlation with clinical outcome and pharmacological aspects underlying its role in the modulation of gemcitabine activity
Elisa Giovannetti1, Niccola Funel2, Ayse Erozenci1, Marco Del Chiaro2, Leticia G. Leon1, Enrico Vasile3, Luca E. Pollina2, Annemieke Groen1, Alfredo Falcone3, Daniela Campani2, Ugo Boggi2, Henk M. Verheul1, Romano Danesi4, Godefridus J. Peters1. 1VU University Medical Center, Amsterdam, Netherlands; 2Divisione di Chirurgia Generale e dei Trapianti dell’Uremico e del Diabetico, Hospital of Pisa, Pisa, Italy; 3Unit of Medical Oncology Azienda Ospedaliero-Universitaria Pisa, Pisa, Italy; 4Dept. Internal Medicine, University of Pisa, Pisa, Italy Minisymposium
MS.CL13.01. Taking Biomarkers into Clinical Practice
Tue, Apr 20, 2:30 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2057/8 – Cigarette smoke enhances pulmonary carcinogenesis via downregulation of has-miR-487b in respiratory epithelial cells
Sichuan Xi1, Maocheng Yang1, Yong-Guang Tao2, Jiqui Shan1, Hong Xu2, Mary Zhang1, David S. Schrump1. 1NCI/NIH, Bethesda, MD; 2NCI/NIH, Frederick, MD Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2087/8 – miR-483-3p is an oncogene involved in nephroblastoma and in adult tumors with activated β-catenin
Angelo Veronese1, Jessica Consiglio1, Rosa Visone1, Nicola Zanesi1, Manuela Ferracin2, Giovanni Lanza2, Patrizia Querzoli2, Adriano Angioni3, Carlo Croce1, Massimo Negrini2. 1Ohio State University, Columbus, OH; 2University of Ferrara, Ferrara, Italy; 3Ospedale Bambin Gesù, Roma, Italy Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4597/8 – MAPK-mediated gene expression in ER-negative breast cancer: Role of miRNAs and Ago2
Philip Miller, Jennifer Clarke, Tulay Koru-Sengul, Joeli Brinkman, Dorraya El-Ashry. Univ. of Miami Sylvester Comp. Cancer Ctr., Miami, FL Poster Session
PO.EN01.01. Regulation of Estrogen Receptor-Positive and -Negative Breast Cancer
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2027/8 – Proteomic analysis identifies pathways regulated by miR-34a
Qing-Rong Chen1, Li-Rong Yu2, Adam Cheuk1, Young Song1, Jun Wei1, Joon-Yong Chung1, Stephen Hewitt1, Timothy D. Veenstra2, Javed Khan1. 1National Cancer Inst., Gaithersburg, MD; 2SAIC-Frederick, Frederick, MD Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Sun, Apr 18, 2:10 – 2:25 PM
13 – Regulation of breast cancer stem cells by miR-93
Suling Liu1, Christophe Ginestier2, Ingrid Ibarra3, Shivani H. Patel1, Amber Heath1, Sing J. Ou1, Raj Jagirdar1, Shawn G. Clouthier1, Hasan Korkaya1, Emmanuelle Charafe-Jauffret2, Gregory J. Hannon3, Daniel Birnbaum2, Max S. Wicha1. 1Univ. of Michigan Comp. Cancer Ctr., Ann Arbor, MI; 2Universite´ de la Me´diterrane´e, Marseille, France; 3Cold Spring Harbor Laboratory, New York, NY Minisymposium
MS.TB02.01. Identification and Targeting of Cancer Stem Cells
Sun, Apr 18, 1:00 – 3:30 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3003/9 – Immune cell-related microRNA-155 is associated with human liver cirrhosis and hepatocellular carcinoma
Anuradha S. Budhu1, Zhipeng Yu1, Marshonna Forgues1, Zhao You Tang2, Carlo M. Croce3, Xin Wei Wang1. 1National Cancer Institute, Bethesda, MD; 2Fudan University and Zhongshan Hospital, Shanghai, China; 3Ohio State University, Columbus, OH Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3004/10 – Specific microRNAs associate with aggressive breast tumor phenotypes in an ethnically diverse patient cohort.
Chika Nwachukwu1, Chunling Zhang1, Shiwei Duan1, Dezheng Huo1, Andy Minn1, Charles Perou2, Olufunmilayo Olopade1. 1University of Chicago, Chicago, IL; 2University of North Carolina, Chapel Hill, NC Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3034/10 – miR-224 is marker of poor prognosis in breast cancer
Sharon F. McGee1, Laoighse Mulrane1, Donal J. Brennan1, Susan McDonnell1, Karin Jirstrom2, Darran P. O’Connor1, William M. Gallagher1. 1University College Dublin, Dublin, Ireland; 2Lund University, Malmo, Sweden Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Wed, Apr 21, 8:00 – 11:00 AM
5355/9 – HPV-16 infection alters cellular microRNA expression in squamous cell carcinoma of the head and neck (SCCHN)
Abigail I. Wald1, Susanne I. Wells2, Robert L. Ferris3, Saleem A. Khan1. 1University of Pittsburgh, Pittsburgh, PA; 2Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; 3University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh, PA Poster Session
PO.CG01.04. Viral Carcinogenesis and Hormonal Carcinogenesis
Wed, Apr 21, 8:00 – 11:00 AM
Mon, Apr 19, 2:00 – 5:00 PM
2088/9 – miR-133a as a tumor suppressive microRNA by targeting multiple oncogenes in head and neck squamous cell carcinoma (HNSCC)
Toyoyuki Hanazawa1, Naoko Kikkawa1, Nijoro Nohata1, Homare Suzuki1, Takeshi Chiyomaru2, Hideki Enokida2, Masayuki Nakagawa2, Yoshitaka Okamoto1, Naohiko Seki1. 1Chiba University, Chiba, Japan; 2Kagoshima University, Kagosima, Japan Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2058/9 – Translational regulation of SPARC by the microRNAs mir29a, b, and c
Vuong Trieu, Larn Hwang, Xiaoqin Lin, Rami Tamir, Kouros Motamed, Neil Desai. Abraxis BioScience, Los Angeles, CA Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4039/9 – miR-196a is a novel diagnostic biomarker and therapeutic target for laryngeal cancer
Koichiro Saito1, Koji Inagaki1, Kosuke Uno1, Yoko Ito2, Toshiaki Sugita2, Satoko Nakajo2, Hideki Naganishi1, Haruna Yabe1, Akira Hirasawa3, Keisuke Okubo4, Kaoru Ogawa1, Takeru Zama1. 1Keio University School of Medicine, Department of Otolaryngology-Head and Neck Surgery, Tokyo, Japan; 2Genetic Testing Section, Center for Genetic & Chromosomal Analysis, SRL, Inc., Tokyo, Japan; 3Keio University School of Medicine, Department of Obstetrics and Gynecology, Tokyo, Japan; 4Sanokousei General Hospital, Department of Otolaryngology, Tochigi, Japan Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 11:55 AM – 12:10 PM
1951 – MicroRNA-mediated regulation of the Fanconi anemia-BRCA pathway
Jen-Wei Huang, Emily Villegas, Toshiyasu Taniguchi. HHMI/Fred Hutchinson Cancer Research Center, Seattle, WA Minisymposium
MS.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 1
Mon, Apr 19, 10:30 AM – 1:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4089/9 – Regulation of cancer-specific microRNA by aberrant DNA methylation in laryngeal cancer
Haruna Yabe, Koichiro Saito, Takahiro Kamimoto, Miwako Kimura, Kaoru Ogawa, Takeru Zama. Keio University School of Medicine, Department of Otolaryngology-Head & Neck Surgery, Tokyo, Japan Poster Session
PO.CB13.06. Noncoding RNAs and Epigenetic Control of MicroRNAs
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3205/9 – Identification of senescence-inducing microRNAs in normal human epithelial cells
Ki-Hyuk Shin, Ana Pucar, Reuben Kim, Mo Kang, No-Hee Park. UCLA School of Dentistry, Los Angeles, CA Poster Session
PO.CB02.01. Telomeres and the Mechanisms of Senescence and Aging
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 9:00 AM – 12:00 PM
1423/12 – SatB2, targeted by miR31, is a modulator in cancer microenvironment
Xiang Yu1, Olga Aprelikova1, John Palla1, Simone John1, Ming Yi2, Robert Stephens2, John I. Risinger3, Amir Jazaeri4, John Niederhuber1. 1National Cancer Institute, Bethesda, MD; 2SAIC Inc, Frederick, MD; 3Michigan State University, Grand Rapids, MI; 4University of Virginia, Charlottesville, VA Poster Session
PO.TB06.02. Stroma 2
Mon, Apr 19, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4040/10 – MicroRNAs that chemosensitize the apoptotic effect of 17-AAG
Larn Hwang, Tina Treece, Neil Desai, Vuong Trieu. Abraxis BioScience, Los Angeles, CA Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4090/10 – RASSF1A gene specific methylation by overexpression of miR-200c in lung cancer.
Sung-Min Chun, Min-Young Jin, Jene Choi, Je-Hwan Lee, Jung Jin Hwang, Chung-Soo Kim, Se Jin Jang. AMC, Seoul, Korea, Republic of Poster Session
PO.CB13.06. Noncoding RNAs and Epigenetic Control of MicroRNAs
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
1987/10 – RNA-seq of the bronchial airway transcriptome identifies novel gene and microRNA expression changes associated with smoking and lung cancer
Jennifer Beane1, Joseph Gerrein2, Jessica Vick1, Yevgeniy Gindin2, Christina Anderlind1, Shawn Levy3, Pierre Massion3, Frank Schembri1, Marc Lenburg1, Avrum Spira1. 1Boston University School of Medicine, Boston, MA; 2Boston University, Boston, MA; 3Vanderbilt University, Nashville, TN Poster Session
PO.CB11.01. Cancer Genomics and Bioinformatics 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3035/11 – MicroRNA expression in early stage endometrial cancers
Gadisetti VR Chandramouli1, Yutaka Shoji1, Yovanni Casablanca2, G. Larry Maxwell2, John I. Risinger1. 1Michigan State University, Grand Rapids, MI; 2Walter Reed Army Medical Center, Washington, DC Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 12:10 – 12:25 PM
1952 – The rapid generation of mouse B cell lymphomas by lentiviral mediated overexpression of miR-1204 from a genetically unstable region of human 8q24
Konrad Huppi1, Brady Wahlberg1, Jason Pitt1, Tamara L. Jones1, Kristen Gehlhaus1, Mark Mackiewicz1, J. Frederic Mushinski1, Vishala Neppalli2, Siegfried Janz2, Natasha J. Caplen1. 1National Cancer Institute, Bethesda, MD; 2University of Iowa, Iowa City, IA Minisymposium
MS.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 1
Mon, Apr 19, 10:30 AM – 1:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2029/10 – Identification of novel tumor suppressor microRNAs implicated in epithelial ovarian cancer from the 19q13.41 non-coding RNA cluster
Preethi Gunaratne1, Rajib Ghosh1, Claire Mach1, Chad J. Creighton2, Douglas A. Levine3, D. Neil Hayes4, David Wheeler2, Martin M. Matzuk2, Matthew L. Anderson2, Richard A. Gibbs2. 1University of Houston, Houston, TX; 2Baylor College of Medicine, Houston, TX; 3Memorial Sloan-Kettering Cancer Center, New York, NY; 4University of North Carolina, Chapel Hill, NC Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2059/10 – The role of microRNA-196b in cervical cancer
Christine How1, Angela B. Hui2, Anthony W. Fyles2, Fei-Fei Liu2. 1University of Toronto, Toronto, ON, Canada; 2Ontario Cancer Institute, University Health Network, Toronto, ON, Canada Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2383/10 – MicroRNA-519c suppresses HIF-1α expression and tumor angiogenesis
Shih-Ting Cha, Pai-Sheng Chen. National Taiwan University, Taipei, Taiwan Poster Session
PO.TB05.04. Molecular Mechanisms of Tumor Angiogenesis
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3005/11 – Significant roles of aberrant miRNA expressions in NK-cell lymphomagenesis
Hiroyuki Tagawa, Yasuo Yamanaka, Atsushi Watanabe, Kenichi Sawada. Akita University Graduate School of Medicine, Akita, Japan Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3006/12 – Alterations of the microRNA genes targeting MYCC are frequent in medulloblastomas with MYCC overexpression
Sheng-Qing Lv1, Young-Ho Kim1, Sumihito Nobusawa1, Michael Grotzer2, Hiroko Ohgaki1. 1Int’l Agency for Research on Cancer, Lyon, France; 2Neuro-Oncology Program, University Children’s Hospital of Zurich, Zurich, Switzerland Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4091/11 – Epigenetic silencing of microRNA in the pathobiology of CLL
Deepa Sampath, Chaomei Liu, William G. Wierda, Michael J. Keating. UT M.D. Anderson Cancer Center, Houston, TX Poster Session
PO.CB13.06. Noncoding RNAs and Epigenetic Control of MicroRNAs
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2090/11 – MicroRNAs 221/222 and genistein mediated regulation of ARHI tumor suppressor gene in prostate cancer
Yi Chen1, Guoren Deng2, Shahana Majid1, Shranjot Saini1, Saif Zaman2, Gaurav Khatri1, Seong O. Suh1, Jan Liu1, Yuichiro Tanaka2, Rajvir Dahiya2. 1Veterans Affairs Medical Center, San Francisco, CA; 2University of California, San Francisco, CA Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 12:25 – 12:40 PM
1953 – Functional identification of microRNA targets by integrated proteomics and microarray profiling: miR-193b in breast cancer
Suvi-Katri Leivonen1, Anne Rokka2, Päivi Östling1, Pekka Kohonen1, Garry Corthals2, Merja Perälä1, Olli Kallioniemi3. 1VTT Medical Biotechnology, Turku, Finland; 2Turku Centre for Biotechnology, Turku, Finland; 3Finnish Institute for Molecular Medicine, Helsinki, Finland Minisymposium
MS.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 1
Mon, Apr 19, 10:30 AM – 1:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2060/11 – microRNA-dependent modulation of histone acetylation in Waldenstrom’s Macroglobulinemia
Aldo M. Roccaro, Antonio Sacco, Abdel Kareem Azab, Feda Azab, Hai T. Ngo, Patricia Maiso, Irene M. Ghobrial. Dana-Farber Cancer Institute, Boston, MA Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4449/11 – Effects of endocrine therapy on mRNA- and microRNA expression profiles in prostate cancer
Saara Lehmusvaara1, Timo Erkkilä2, Harri Lähdesmäki2, Paula Kujala3, Teuvo L.J. Tammela4, Tapio Visakorpi1. 1Institute of Medical Technology, University of Tampere, Tampere, Finland; 2Department of Signal Processing, Technical University of Tampere, Tampere, Finland; 3Department of Pathology, Tampere University Hospital, Tampere, Finland; 4Department of Urology, Tampere University Hospital, Tampere, Finland Poster Session
PO.ET03.03. Novel Mechanisms of Drug Action
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 4:25 – 4:40 PM
2915 – p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
Kaori Fujita1, Abdul M. Mondal1, Izumi Horikawa1, Giang H. Nguyen1, Kensuke Kumamoto1, Jane J. Sohn1, Elise D. Bowman1, Mathe A. Mathe1, Aaron J. Schetter1, Sharon R. Pine1, Helen Ji1, Borivoj Vojtesek2, Jean-Christophe Bourdon3, David P. Lane3, Curtis C. Harris1. 1National Cancer Inst., Bethesda, MD; 2Masaryk Memorial Cancer Institute, Brno, Czech Republic; 3University of Dundee, Dundee, United Kingdom Minisymposium
MS.CB02.01. Mechanisms of Cell Death, Survival, and Senescence
Mon, Apr 19, 2:30 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2841/11 – A SNP in the 3′-UTR of the MDMX gene is strongly correlated with decreased overall and disease-free survival in ovarian carcinoma patients in an estrogen-receptor-dependent manner
Anja Boehnke1, Jessica Wynendale2, Irina Lambertz2, Anja Wolf1, Stefanie Hammer1, Elise Gradhand1, Katharina Balschun3, Steffen Hauptmann1, Jean-Christophe Marine2, Frank Bartel1. 1Institute of Pathology, Halle/Saale, Germany; 2VIB Laboratory UGent, Gent, Belgium; 3Institute of Pathology, Kiel, Germany Poster Session
PO.EP03.03. Polymorphisms in Genes Related to Cell Growth, Differentiation, and Hormone Metabolism
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3036/12 – Comparison of miRNA expression between human osteoblasts and osteosarcoma cells
Zhenfeng Duan, Edwin Choy, David Harmon, Xianzhe Liu, Michiro Susa, Joe Schwab, Henry Mankin, Francis Hornicek. Massachusetts General Hospital, Boston, MA Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4041/11 – Lipofection of the designed plasmid expressing microRNA-7 has antitumor effect in gefitinib-resistant lung adenocarcinoma in vivo
Kammei Rai, Nagio Takigawa, Sachio Ito, Hiromi Kashihara, Eiki Ichihara, Katsuyuki Kiura, Tatsuji Yasuda, Kenji Shimizu, Mitsune Tanimoto. Okayama University, Okayama, Japan Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
3903/11 – Mybl2, a link between proliferation and differentiation in maturing colon epithelial cells
Michael Papetti, Leonard H. Augenlicht. Montefiore Medical Center, Bronx, NY Poster Session
PO.CB05.02. Developmental Gene Expression Pathways
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3007/13 – Hsa-miR-9 expression patterns are associated with metastatic recurrence in patients with clear cell renal cell carcinoma through hypermethylation of the gene in tumor tissue
Michelle A.T. Hildebrandt, Jian Gu, Jie Lin, Yuanqing Ye, Weiqi Tan, Pheroze Tamboli, Christopher G. Wood, Xifeng Wu. UT M.D. Anderson Cancer Center, Houston, TX Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3037/13 – Integrated Genomic, MicroRNA (miRNA) and Proteomic Profiling of Ovarian Carcinoma for Biomarker Discovery
Jane Bayani1, Uros Kuzmanov1, Ihor Batruch2, Chan-Kyung Cho3, Chris Smith2, Paula Marrano4, Cassandra Graham5, Ralf Butzow6, Dionyssios Katsaros7, Li Lin8, Yingye Zheng8, Jeremy A. Squire9, Eleftherios P. Diamandis1. 1University of Toronto/Mt. Sinai Hospital, Toronto, ON, Canada; 2Toronto General Hospital, University Health Network, Toronto, ON, Canada; 3University of Toronto/University Health Network, Toronto, ON, Canada; 4Hospital for Sick Children, Toronto, ON, Canada; 5University of Toronto/Hospital For Sick Chidren, Toronto, ON, Canada; 6University of Helsinki, Helsinki, Finland; 7University of Turin, Turin, Italy; 8Fred Hutchinson Cancer Research Center, Seattle, WA; 9Queen’s Univeristy, Kingston, ON, Canada Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4042/12 – MiR-200c sensitizes colorectal cancer cells to 5-FU through Bcl-2-involved apoptotic pathway
Xuemin Qian, Paul Howell, Xiaobo Li, Xin Qin, Lin Gao, Yaguang Xi. Univ. of South Alabama Mitchell Cancer Inst., Mobile, AL Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2091/12 – MiR-145 functions as a potential tumor suppressor in hepatocellular carcinoma
Priscilla TY LAW, Arthur KK Ching, Queenie WL Wong, Paul BS Lai, Nathalie Wong. The Chinese University of Hong Kong, Hong Kong, Hong Kong Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2061/12 – Vitamin D-regulates microRNAs in primary cultures of normal prostatic epithelial cells
Angeline Antonio, Avani Vaishnav, Larisa Nonn. University of Illinois Chicago, Chicago, IL Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4092/12 – Aberrant miRNA methylation in tumors from surgically resected lung cancer patients and association with survival
Weiqi Tan, Jian Gu, Michelle Hildebrandt, Maosheng Huang, Ignacio I. Wistuba, Jack A. Roth, Margaret R. Spitz, Xifeng Wu. The University of Texas M. D. Anderson Cancer Center, Houston, TX Poster Session
PO.CB13.06. Noncoding RNAs and Epigenetic Control of MicroRNAs
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4093/13 – miR-193b is an epigenetically regulated putative tumor suppressor in prostate cancer
Hanna E. Rauhala1, Sanni E. Jalava1, Jarkko Isotalo1, Hazel Bracken1, Saara Lehmusvaara1, Hannu Oja2, Teuvo L. Tammela3, Tapio Visakorpi1. 1Univ. of Tampere Inst. of Med. Tech., Tampere, Finland; 2University of Tampere, School of Public Health, Tampere, Finland; 3University of Tampere and Tampere University Hospital, Department of Urology, Tampere, Finland Poster Session
PO.CB13.06. Noncoding RNAs and Epigenetic Control of MicroRNAs
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2032/13 – MicroRNA control of tumor cell plasticity in a new tumor metastasis model
Jacqueline Banyard, Arianne M. Wilson, Diane R. Bielenberg, Bruce R. Zetter. Children’s Hospital Boston, Boston, MA Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4680/13 – Correlation between Wnt pathway and colorectal cancer recurrence using protein, mRNA and microRNA analysis
Renata A. Coudry, Mila O. Martins, Cláudia M C Coutinho, Marcilei Buim, Kátia C. Carvalo, Erika M. Santos, Helena Brentani. Fundaçao Antonio Prudente, São Paulo, Brazil Poster Session
PO.CL03.02. Correlative and Basic Science in Cancer
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4043/13 – Targeting microRNA for the prevention and treatment of prostate cancer
Raj Kumar, Srinivas Koduru, Sowmyalakshmi Srinivasan, Jurgen Rohr, Chendil Damodaran. Univ. of Kentucky, Lexington, KY Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2062/13 – A quantitative proteomic investigation of microRNA-145 in breast cancer.
Nicholas W. Bateman, Brian L. Hood, Mai Sun, Thomas P. Conrads. Univ. of Pittsburgh, Pittsburgh, PA Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2092/13 – Control of histone 3 lysine 27 methylation by microRNA 520b in medulloblastoma
Irina Alimova, Sujatha Venkataraman, Purvi Patel, Peter Harris, Rajeev Vibhakar. UC Denver, Aurora, CO Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4069/13 – The p47 Phox mediated redox-signal promotes myogenesis via p38 MAPK regulated microRNA-206
Junkyu Song, Young Eun Choi, Hye Ok Kim, Chang Hoon Cho, Kyung-Sik Yoon, Department of Biochemistry and Molecular Biology(BK21 project), MRC for Bioreaction to ROS and B. Graduate School of Medicne, Kyung Hee University, Seoul, Korea, Republic of Poster Session
PO.CB05.03. Modulating Gene Expression
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3038/14 – Determination of microRNA expression profile in tumors from young women with breast cancer
Elen P. Bastos1, Helena P. Brentani2, Dirce M. Carraro2, Maria I. Achatz2, Eloisa H. Olivieri2, Maria S. Maciel2, Rodrigo Michelli3, Maria Mitzi Brentani1. 1Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; 2Hospital A. C. Camargo, São Paulo, Brazil; 3Hospital de Cancer de Barretos, São Paulo, Brazil Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3008/14 – PNA based microarray for cancer & stem cell related miRNAs profiling from low total RNA with on-chip labeling
Kim Hyunsun, Jae-Jin Choi, Minhye cho, Heekyung Park. Panagene Inc., Daejeon, Korea, Republic of Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2033/14 – Regulatory role of miR-203 in prostate cancer
Sharanjot Saini1, Shahana Majid1, Guoren Deng2, Soichiro Yamamura1, Koji Ueno1, Yi Chen1, Saif Zaman2, Rajvir Dahiya2. 1VA Medical Center, San Francisco, CA; 2VA Medical Center and UCSF, San Francisco, CA Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3009/15 – Evaluating the role of cell cycle inhibition in celecoxib toxicity through microRNA analysis
Andrew C. Heaford1, Christy B. Erbe2, Jonathan M. Bock2. 1University of Iowa, Iowa City, IA; 2Medical College of Wisconsin, Milwaukee, WI Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3039/15 – microRNA profiling of gastric cancer patients from formalin-fixed paraffin-embedded (FFPE) samples
Yutaka Shimada1, Tomoyuki Okumura1, Soshi Osawa1, Shin-ichi Sekine1, Makoto Moriyama1, Shigeaki Sawada1, Takuya Nagata1, Hiroyuki Takahashi1, Junya Fukuoka1, Yasuo Takano1, Manabu Fukumoto2, Kazuhiro Tsukada1. 1Univ. of Toyama, Toyama, Japan; 2Tohoku Univ., Sendai, Japan Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4044/14 – microRNA mimics as cancer therapeutics
Chritopher L. Daige1, Robert B. Fields1, ChuanYu Li1, Will Cantley2, Akin Akinc2, Balkrishen Bhat1, Eric G. Marcusson1, Peter S. Linsley1. 1Regulus Therapeutics, Carlsbad, CA; 2Alnylam Pharmaceuticals, Boston, MA Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2063/14 – Reversal of chemoresistance to Paclitaxel by reintroduction of microRNA-200c in ovarian cancer cells
Jennifer K. Richer1, Irina Dimitrova2, Miriam Post2, Kian Behbakht2. 1Univ. of Colorado Denver and Health Sci. Prog., Aurora, CO; 2Univ. of Colorado Denver, Aurora, CO Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2093/14 – Functional screening of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral squamous cell carcinoma
Ken-ichi Kozaki1, Atsushi Uesugi2, Mayuko Furuta3, Issei Imoto3, Johji Inazawa3. 1Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan; 2Department of Oral and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan; 3Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 9:00 AM – 12:00 PM
1856/15 – A KRAS-variant as a putative biomarker of ovarian cancer risk
Joanne B. Weidhaas, Frank Slack. Yale Univ. School of Medicine, New Haven, CT Poster Session
PO.EP03.04. Hereditary Cancer and Polymorphisms in DNA Repair
Mon, Apr 19, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2094/15 – MicroRNA expression signatures in hypopharyngeal squamous cell carcinoma (HSCC): miR-489 inhibits cell proliferation by targeting PTPN11
Nijiro Nohata, Toyoyuki Hanazawa, Naoko Kikkawa, Homare Suzuki, Yoshitaka Okamoto, Naohiko Seki. Chiba University, Chiba, Japan Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2064/15 – Down-regulation of miR-31 is associated with metastatic potential of human and canine osteosarcoma
Tamene Melkamu1, Daniel F. Carlson1, James P. Farese2, Fekadu Kassie1. 1University of Minnesota, Minneapolis, MN; 2University of Florida, Gainesville, FL Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 9:00 AM – 12:00 PM
1180/15 – MicroRNAs and their target messenger RNAs associated with progression of breast cancer
Silke Schultz1, Karina Petat-Dutter2, Michael Walter3, Sven Poths3, Ulrich Vogel4, Michael Bonin3, Karl Sotlar2, Christina Neuburger1, Diethelm Wallwiener1, Tanja Fehm1, Hans J. Neubauer1. 1Department of Obstetrics and Gynecology, Tuebingen, Germany; 2Institute for Pathology, Munich, Germany; 3Microarray Facility Tuebingen, Tuebingen, Germany; 4Institute for Pathology, Tuebingen, Germany Poster Session
PO.CB03.01. Molecular Markers
Mon, Apr 19, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3010/16 – The advent of miRNAs in the molecular taxonomy of breast cancer
Francesca Biagioni1, Noa Bossel2, Giulia Fontemaggi1, Barbara Antoniani1, Anna Di Benedetto1, Sabrina Strano1, Paola Muti1, Marcella Mottolese1, Eytan Domany2, Giovanni Blandino1. 1Regina Elena National Cancer Institute, Rome, Italy; 2Weizmann Institute of Science, Rehovot, Israel Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2034/15 – Tumor suppressive activity of Smad3 by regulation of microRNAs in gastric cancer
Jooyoung Kim1, Dong-Kyun Park2, Sung-Min Ahn1, Jiyoung Cha1, Suntaek Hong1. 1Lee Gil Ya Cancer and Diabetes Institute, Incheon, Korea, Republic of; 2Gachon University of Medicine and Science, Incheon, Korea, Republic of Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Sun, Apr 18, 2:00 – 5:00 PM
47/15 – Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells
Benjamin A. Kefas. Univ. of Virginia, Charlottesville, VA Poster Session
PO.CB09.01. Cancer Cell Metabolism 1
Sun, Apr 18, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4095/15 – Aberrant expression of epigenetically regulated microRNAs in liver cancer
Chun-Ming Wong, Carmen Chak-Lui Wong, Aegean Hoy Kam Tam, Irene Oi-Lin Ng. University of Hong Kong, Pokfulam, Hong Kong Poster Session
PO.CB13.06. Noncoding RNAs and Epigenetic Control of MicroRNAs
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4045/15 – Restoring miR-15a/16 in the NZB mouse model of chronic lymphocytic leukemia reduces disease and enhances drug sensitivity
Erica Salerno1, Yao Yuan1, Frederick D. Coffman1, Brian J. Scaglione2, Brian D. Brown2, Desiree Bonci3, Elizabeth S. Raveche1. 1UMDNJ, Newark, NJ; 2Mount Sinai School of Medicine, New York, NY; 3Istituto Superiore Sanita, Rome, Italy Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4046/16 – Androgen-mediated phenotypic change in prostate carcinoma cells and the microRNA-ome
Corrinne Segal1, Chris J. Powell2, Nigel J. Gooderham1. 1Imperial College, London, United Kingdom; 2GlaxoSmithKline, Ware, United Kingdom Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2035/16 – The levels of miR-145 are regulated by DNA methylation and p53 gene status in prostate cancer
Seong O Suh, Mohd Saif Zaman, Varahram Shahryari, Yi Chen, Jan Liu, Z. Laura Tabatabai, Sanjay Kakar, Guoren Deng, Rajvir Dahiya. VA Medical Center San Francisco, San Francisco, CA Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3041/17 – Differential expression of microRNAs between sporadic and hereditary nonmedullary thyroid cancer
Yin Xiong, Electron Kebebew. NCI, Bethesda, MD Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4096/16 – Diffused intrinsic pontine glioma: An analysis of coding and non-coding RNA species
Annie Sandza1, Tobey J. MacDonald2, D. Ashley Hill1, Javad Nazarian1. 1Children’s National Medical Center, Washington, DC; 2Children’s Healthcare of Atlanta/Emory University, Atlanta, GA Poster Session
PO.CB13.06. Noncoding RNAs and Epigenetic Control of MicroRNAs
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4360/16 – Loss of NOTCH1 is associated with decreased expression of hsa-miR-125a-5p in T-cell acute lymphoblastic leukemia: Implications for using NOTCH1 inhibition in chemotherapy
Amanda L. Larson Gedman, Alan Dombkowski, Yubin Ge, Jeffrey W. Taub, Larry H. Matherly. Wayne State University, Detroit, MI Poster Session
PO.TB08.01. Pediatric Brain Tumors and Leukemia
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2065/16 – DDX20 deficiency enhances NF-κB by impairing NF-κB suppressive-microRNA function and leads to hepatocarcinogenesis
Akemi Takata, Motoyuki Otsuka, Yotaro Kudo, Kentaro Kojima, Shin Maeda, Keisuke Tateishi, Tsuneo Ikenoue, Hideaki Ijichi, Yoshihiro Hirata, Haruhiko Yoshida, Masao Omata, Kazuhiko Koike. University of Tokyo, Tokyo, Japan Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Wed, Apr 21, 8:00 – 11:00 AM
4906/16 – Integrated analysis of epigenetic signatures associated with inflammatory breast cancer
Steven Van Laere1, Ilse Van der Auwera1, Wayne Yu2, Peter van Dam1, Patrick Pauwels1, Eric Van Marck1, Peter Vermeulen1, Luc Dirix1. 1Translational Cancer Research Group (Laboratory of Pathology, University of Antwerp/University Hospital Antwerp; Oncology Center, Sint-Augustinus), Antwerp, Belgium; 2Department of Oncology and the Sydney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD Poster Session
PO.CB06.04. DNA Methylation 3
Wed, Apr 21, 8:00 – 11:00 AM
Tue, Apr 20, 9:00 AM – 12:00 PM
3011/17 – MicroRNA expression profiles in benign and aggressive canine mast cell tumors
Joelle M. Fenger1, Tzu-yin Lin2, Cristian Taccioli3, Stefano Volinia3, William C. Kisseberth1, Cheryl A. London2. 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH; 2Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH; 3Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2095/16 – The functional significance of microRNA-145 in prostate cancer
Mohd S. Zaman, Guoren Deng, Varahram Shahryari, Seong O. Suh, Yi Chen, Yuichiro Tanaka, Rajvir Dahiya. UCSF and VA Medical Center, San Francisco, CA Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Sun, Apr 18, 2:00 – 5:00 PM
595/16 – Single adenovirus-mediated simultaneous expression of p53 and the artificial microRNAs targeting anti-apoptotic p53 target genes
Masashi Idogawa, Yasushi Sasaki, Kohzoh Imai, Yasuhisa Shinomura, Takashi Tokino. Sapporo Medical University, Sapporo, Japan Poster Session
PO.ET08.01. Gene and Vector-Based Therapy 1
Sun, Apr 18, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4073/17 – The PNA oligonucleotide is effective miRNA inhibitor that transfection reagents are not required
Su Young Oh, Yeong Soon Ju, Seryun Kim, Heekyung Park. Panagene, Daejeon, Korea, Republic of Poster Session
PO.CB05.03. Modulating Gene Expression
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3012/18 – Development of a microRNA signature for risk of progression in renal cell carcinoma
Gowrishankar Banumathy, Ilsiya Ibragimova, Tahseen Al-Saleem, Robert G. Uzzo, Paul Cairns. Fox Chase Cancer Ctr., Philadelphia, PA Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2096/17 – The role of microRNA-1 as a candidate tumor suppressor in cutaneous squamous cell carcinoma
Dustin L. Gable, Jessica L. Fleming, Amanda Ewart Toland. Ohio State Univ., Columbus, OH Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2066/17 – Role of miR-182/miR-96 cluster in prostatic zinc homeostasis
Ekaterina A. Khramtsova, Avani Vaishnav, Nicoleta Arva, Angeline Antonio, Andre Kajdacsy-Balla, Larisa Nonn. Univ. of Illinois, Chicago, IL Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2036/17 – MicroRNA-137 reverse the malignant phenotypes of colorectal cancer cells by targeting small GTPase Cdc42
FENG BI, Ming Liu, Nan Lang, Qiuling Tang. Dept. of Medical Oncology, West China Hospital, Sichuan University, Chengdu, China Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3042/18 – Investigating microRNA expression profiles in colon cancer cells in response to cyclooxygenase 2 signaling
Kelsey L. Harpster, Ronald R. Bean, Rolf Jakobi, Yu-Wen E. Chang. KCUMB, Kansas City, MO Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4047/17 – Mining of microRNA signatures in endometrial cancer
Yick Fu Wong1, T.H. Cheung1, S.F. Yim1, T.S. Lau1, L.K.Y. Chan1, S.W. Ng2, T.K.H. Chung1. 1The Chinese University of Hong Kong, Shatin, NT, Hong Kong; 2Brigham & Women’s Hospital, Harvard Medical School, Boston, MA Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3542/17 – Analysis of miRNA mediated Cisplatin resistant mechanisms
Toshihiro Suzuki1, Kazuto NIshio2, Tadayasu Togawa1, Kanako Sugawara1, Hitoshi Sakuraba1. 1Meiji Pharmaceutical Univ., Tokyo, Japan; 2Kinki University, Osaka, Japan Poster Session
PO.ET04.04. Mechanisms of Resistance 4: Drug Transporters and Chemotherapeutics
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4048/18 – Increased expression of PACS-1 in cervical cancer is associated with loss of microRNA449a
Mysore S. Veena1, Santanu Raychaudhuri2, Huihong You3, Saroj K. Basak4, Kayvan Zainabadi5, Gary Thomas3, Eri Srivatsan6. 1UCLA VA Greater LA Healthcare System, Los Angeles, CA; 2UCLA, Los Angeles, CA; 3Vollum Institute, Oregon Health and Science University, Portland, OR; 4VA Greater LA Healthcare System and UCLA, Los Angeles, CA; 5MIT, Boston, MA; 6VA Greater LA Healthcare System and UCLA, Los Angeles, CA Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4786/18 – MiR-17-92 expression in differentiated T cells – Implications for cancer immunotherapy
Gary Kohanbash, Kotaro Sasaki, Aki Hoji, Mitsugu Fujita, Hideho Okada. University of Pittsburgh Cancer Institute, Pittsburgh, PA Poster Session
PO.IM01.03. Tumor Antigens and Adaptive Immunity
Tue, Apr 20, 2:00 – 5:00 PM
Sun, Apr 18, 2:00 – 5:00 PM
483/18 – Genome-wide analysis identify molecular regulators of metastasis
Seongho Ryu, Vivek Mittal. Weill Cornell Medical College, New York, NY Poster Session
PO.TB01.06. Model Systems in the Study of Metastasis
Sun, Apr 18, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3013/19 – Differential approach to define microRNA expression patterns in osteosarcomas
Luisa Montanini1, Laura Pazzaglia2, Paola Spessotto3, Jørgen Kjems4, Amalia Conti2, Roberto Perris1, Monique L. den Boer5, Maria Serena Benassi2. 1Center for Molecular and Translational Oncology- Parma University, Parma, Italy; 2Experimental Oncology Laboratory- Istituto Ortopedico Rizzoli, Bologna, Italy; 3Experimental Oncology 2, Dept Molecular Oncology- CRO, Aviano, Italy; 4Department of Molecular Biology-Aarhus University, Aarhus, Denmark; 5Erasmus University Medical Center, Rotterdam, Netherlands Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2037/18 – Anti-miRNA-21 confers radiosensitivity through inhibition of PI3K/AKT pathway and enhancing autophagy
Ho-Shin Gwak, Tae Hoon Kim, Seung Hoon Lee, Heon Yoo, Jong Bae Park. National Cancer Center Korea, Goyang, Korea, Republic of Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3043/19 – Microarray based profiling reveals a distinct set of differentially expressed miRNAs in pancreatic cancer
Eeva Laurila1, Saana Sandstrom2, Reija Autio2, Anne Kallioniemi1. 1University of Tampere, Tampere, Finland; 2Tampere University of Technology, Tampere, Finland Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2097/18 – microRNA profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma
Jian-jun Zhao, Jianhong Lin, Tint Lwin, Hua Yang, Jianping Guo, William Kong, Sophie Dessureault, Lynn Moscinski, Dorna Rezania, William S. Dalton, Eduardo Sotomayor, Jianguo Tao, Jin Q. Cheng. H. Lee Moffitt Cancer Ctr. & Res. Inst., Tampa, FL Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2067/18 – Effects of microRNA-34a on brain tumor cells and glioblastoma stem cells
Fadila Guessous, Ying Zhang, Alessia Catania, Yunqing Li, Alexander Kofman, Benjamin Kefas, David Schiff, Benjamin Purow, Roger Abounader. Univ. of Virginia, Charlottesville, VA Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2098/19 – The receptor tyrosine kinase AXL is a target for the human miR-34a microRNA
Mark Mackiewicz, Konrad Huppi, Robert Cornelison, Natasha J. Caplen. National Cancer Institute, NIH, Bethesda, MD Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2068/19 – Profile, target genes and regulation of microRNAs in ovarian carcinoma tumor progression.
Olga Vaksman1, Ben Davidson2, Claes G. Trope’3, Janne Kaern3, Reuven Reich1. 1Institute of Drug Research, Faculty of Medicine, Hebrew University, Jerusalem, Israel; 2Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway; 3Section for Gynecologic Oncology, Division of Obstetrics and Gynecology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3044/20 – Enzymatic bioluminescence assay for microRNA quantification
Ye Sun, Val Golovlev. Sci-Tec, Inc., Knoxville, TN Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2038/19 – miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells
Ruey-Jen Lin1, You-Chin Lin2, Alice L. Yu2. 1Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan; 2Genomics Research Center, Academia Sinica, Taipei, Taiwan Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3014/20 – Robust microRNA expression profiling of specific cells in complex archival tissue stained by immunohistochemistry
Falk Hlubek1, Claudia Schuster1, Jan Budczies2, Thomas Kirchner1. 1Institute of Pathology, University of Munich LMU, Munich, Germany; 2Institute of Pathology, Charité-Universitätsmedizin, Berlin, Germany Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4049/19 – MiR-187 is a marker of poor prognosis in estrogen receptor-positive breast cancer
Laoighse Mulrane1, Stephen Madden1, Donal J. Brennan2, Sharon F. McGee1, Karin Jirström3, Laura van’t Veer4, Rene Bernards4, Des Higgins1, William M. Gallagher1, Darran P. O’Connor1. 1University College Dublin, Dublin, Ireland; 2University College Cork, Cork, Ireland; 3Malmö University Hospital, Lund University, Lund, Sweden; 4Netherlands Cancer Institute, Amsterdam, Netherlands Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 9:00 AM – 12:00 PM
1328/20 – p53 represses microRNAs let-7a and let-7b in response to ionizing radiation
Anthony D. Saleh1, Jason E. Savage1, David Ly1, Phuongmai Nguyen1, Lui Cao2, Benjamin P. Soule1, Tu D. Dan1, William DeGraff1, Toren Finkel2, Curtis C. Harris1, James B. Mitchel1, David Gius1, Nicole L. Simone1. 1National Cancer Inst., Bethesda, MD; 2National Heart Lung and Blood Institute, Bethesda, MD Poster Session
PO.TB09.01. DNA Damage Response, Signaling, and Gene Expression
Mon, Apr 19, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4050/20 – Normalization of TaqMan human microRNA array data using average expression of controls.
Gadisetti VR Chandramouli1, G. Larry Maxwell2, John I. Risinger1. 1Michigan State University, Grand Rapids, MI; 2Walter Reed Army Medical Center, Washington, DC Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2069/20 – Combinatorial microRNA activity associated with breast cancer metastasis is revealed through computational analysis of target genes and pathways.
Alan A. Dombkowski, Zakia Sultana, Hasan Jamil, Douglas Craig. Wayne State University, Detroit, MI Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3045/21 – Identification of specific microRNA signatures in VHL-functional and VHL-silenced renal cell carcinoma cell lines
Vittal Kurisetty1, Lellean JeBailey2, Tony Luongo3, Jaime R. Merchan4. 1University of Miami, Miami, FL; 2GeneGO Inc., Miami, FL; 3Tufts Medical Center, Boston, MA; 4University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3046/22 – Differential microRNA patterns in prostate carcinoma cells after single and fractionated radiation
Molykutty J. Aryankalayil, Sanjeewani T. Palayoor, David Cerna, C.Norman Coleman. National Insts. of Health, Bethesda, MD Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2100/21 – Down regulation of HOXD10 by microRNA-10b enhances proliferation of glioblastoma multiforme derived cell lines
Arti B. Gaur, Mark A. Israel. Dartmouth Medical School, Lebanon, NH Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2070/21 – Mir-199a is downregulated in hypoxia and targets HIF1α in ovarian cancer cells
Hemant Joshi, Indira Subramanian, Goutam Ghosh, Yan Zeng, Min Zhao, Sundaram Ramakrishnan. University of Minnesota, Minneapolis, MN Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4051/21 – MiR-181b expression levels decreases during the progression of the Chronic Lymphocytic Leukemia: a new potential prognostic tool
Rosa Visone1, Angelo Veronese1, Laura Z. Rassenti2, Veronica Balatti1, Cristian Taccioli1, Thomas J. Kipps2, Carlo M. Croce1. 1The Ohio State University, Columbus, OH; 2University of California, San Diego, CA Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2040/21 – Identification of microRNAs associated with tamoxifen resistance in breast cancer
Lai-yee Lau, Kelvin Yuen-kwong Chan, Ui-Soon Khoo. The University of Hong Kong, Hong Kong, Hong Kong Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 9:00 AM – 12:00 PM
1156/21 – Applying targeted Next-Gen Sequencing and miRNA expression profiling for cancer biomarker discovery
Jack T. Leonard. febit inc., Lexington, MA Poster Session
PO.CB12.01. Innovative Technologies 1
Mon, Apr 19, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3016/22 – The value of microRNAs in the detection and staging of colorectal cancer
Nadia Ilyayev1, Alexander Stojadinovic2, David Halle1, Marina Roistacher1, Vera Pavlov1, Stella Mitrani-Rosenbaum1, Aviram Nissan1. 1Hadassah-Hebrew University Medical Center, Jerusalem, Israel; 2Walter Reed Army Medical Center, Washington, DC Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Wed, Apr 21, 8:00 – 11:00 AM
5162/21 – MicroRNA regulation of epidermal lineage differentiation of NT2/D1 embryonal carcinoma cells
Ritu Kushwaha, Venkata Thodima, George J. Bosl, Raju S.K Chaganti. MSKCC, New York, NY Poster Session
PO.TB02.07. Cancer Stem Cell Biology 3
Wed, Apr 21, 8:00 – 11:00 AM
Wed, Apr 21, 8:00 – 11:00 AM
4882/22 – Loss of p300 reduces miR-let-7c and enhances ER-positive breast cancer cell tumorigenicity
Huijun Yuan, Sukanya Sil, Salil Sharma, Nanette Bishopric. University of Miami, Miami, FL Poster Session
PO.CB06.03. Chromatin Modifications
Wed, Apr 21, 8:00 – 11:00 AM
Tue, Apr 20, 9:00 AM – 12:00 PM
3017/23 – MicroRNAs as prognostic indicators in gastric cancer
Michal Kushnir1, Moshe B. Hoshen1, Ofer Purim2, Eti Meiri1, Hila Cholakh1, Naama Barabash1, Yaron Goren1, Gideon Marshak2, Yulia Kundel2, Sara Morgenstern2, Marisa Halpern2, Yaron Niv2, Ayelet Chajut1, Baruch Brenner2. 1Rosetta Genomics, Rehovot, Israel; 2Rabin Medical Center, Petah Tikva, Israel Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2071/22 – Loss of ER-regulated microRNAs is fundamental to hormone-independent breast cancer cells
Shannon T. Bailey, Hansen H. He, Myles Brown. Harvard Medical School / Dana-Farber Cancer Institute, Boston, MA Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2041/22 – PDGF inducible microRNAs regulate gene expression in cancer cells
Minghai Shao1, Simona Rossi2, Bhadrani Chelladurai1, Obiageli Ntukogu1, Mircea Ivan1, George Calin2, Daniela Matei1. 1Indiana University, School of Medicine, Indianapolis, IN; 2The University of Texas M. D. Anderson Cancer Center, Houston, TX Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3047/23 – 2-Methoxyestradiol inhibits proliferation and induces apoptosis through modulation of miR-7/FLIP signaling in prostate cancer cells
Saikartik Kumar1, Rita Ghosh2, Addanki P. Kumar2. 1Ronald Regan High School, San Antonio, TX; 2UT Health Science Ctr., San Antonio, TX Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3018/24 – Identifying and characterizing subpopulation of exosomes to provide the foundation for a novel exosome-based cancer diagnostic platform
Traci L. Pawlowski, David Spetzler, Teresa Tinder, Paula Esmay, Amber Conrad, Phil Ellis, Patrick Kennedy, Annemarie Tyrell, Unnati Jariwala, Christine Kuslich. CarisDX, Phoenix, AZ Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2042/23 – Aberrant expression of miR-21 triggers malignancy of human gliomas by disrupting negative feedback regulator, Spry2
Youn-Jae Kim, Hee-Jin Kwak, Jong Bae Park, Seung-Hoon Lee. National Cancer Center, Goyang-si, Korea, Republic of Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3048/24 – microRNA biomarkers associated with sunitinib-resistance in non-small cell lung cancer
Kristen M. Nelson1, Chao Sima1, David K. Edwards, V1, Glen J. Weiss2. 1TGen, Phoenix, AZ; 2Scottsdale Clinical Research Institute/TGen, Phoenix, AZ Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4053/23 – One MicroRNA Has Prognostic Potential For Malignant Pleural Mesothelioma
Ayelet Chajut1, Harvey Pass2, Chandra Goparaju2, Dalia Cohen3, Harel Dan1, Sergey Ivanov2, Hadas Gibori1, Shai Rosenwald1, Jessica Donington2, Nir Dromi1, Moshe Hoshen1. 1Rosetta Genomics, Rehovot, Israel; 2Thoracic Surgery, NYU Langone Medical Center, NY, NY; 3Rosetta Genomics Inc, Philadelphia, PA Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2102/23 – Exogenous microRNA-101 suppresses cell proliferation by downregulation of cyclooxygenase-2 expression in prostate cancer cell line
Yubin Hao1, Xiaowu Pang1, Yuan Zhao1, Joseph A. Califano2, Xinbin Gu1. 1Howard Univ. College of Dentistry, Washington, DC; 2Johns Hopkins Medical Institutions, Baltimore, MD Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2072/23 – Systematic functional analysis of microRNAs by transfection of 1129 miRNAs into prostate cancer cells
Paivi Ostling1, Suvi-Katri Leivonen1, Anna Aakula2, Pekka Kohonen1, Rami Makela1, Merja Perala1, Olli Kallioniemi3. 1VTT – Technical Research Centre of Finland, Turku, Finland; 2University of Turku, Turku, Finland; 3FIMM – Institute for Molecular Medicine Finland, Helsinki, Finland Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2073/24 – Changes in microRNA expression in response to short-term chemotherapeutic exposure is associated with transient anticancer drug resistance
Tsui-Ting Ho1, Xiaolong He1, Ahmet Dirim Arslan1, Yin-Yuan Mo2, William T. Beck1. 1University of Illinois at Chicago, Chicago, IL; 2Southern Illinois University, Springfield, IL Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3019/25 – MicroRNAs as a powerful diagnostic tools for the differential diagnosis of kidney tumors
Yael Spector1, Eddie Fridman2, Iris Barshack2, Zohar Dotan3, Jacob Ramon3, Nitzan Rosenwald1, Ranit Aharonov1, Sarit Tabak1, Sima Banjamin1, Avital Dov1, Miriam Ben David1, Orit Zion1, Hila Banjamin1, Alexander Faerman1. 1Rosetta Genomics, Rehovot, Israel; 2Department of Pathology, Sheba Medical Center, Tel-Hashomer, Israel; 3Department of Urology, Sheba Medical Center, Tel-Hashomer, Israel Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2103/24 – miR-140 and miR-192 are potential tumor suppressors through inhibiting cellular proliferation and restoring cell cycle control in breast cancer cell lines
Bo Song, Mihriban Karaayvaz, Jingfang Ju. Univ. of Stony Brook, Stony Brook, NY Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3549/24 – miR-451 links CRC stem-like cells with chemoresistance
Nerea Bitarte1, Valentina Boni1, Ruth Zarate1, Marisol Gonzalez-Huarriz1, Ines Lopez1, Javier Rodriguez2, Eva Bandres1, Jesus Garcia-Foncillas1. 1Laboratory of Pharmacogenomics, Division of Oncology, Center for Applied Medical Research (CIMA), Pamplona, Spain; 2Department of Oncology, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain Poster Session
PO.ET04.04. Mechanisms of Resistance 4: Drug Transporters and Chemotherapeutics
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2043/24 – Inhibition of cervical carcinoma cells proliferation by miR-34c
Jesus A. Lopez, Luis M. Alvarez Salas. CINVESTAV, Mexico City, Mexico Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3049/25 – Overexpression of miR-17 family miRNAs in prostate cancer biopsies: Evidence for a stem-cell-like miRNA profile in high grade/high stage tumors
Sandra M. Gaston1, Andrew L. Guerra1, Rangarajan C. Nadadur1, Julie Meadows1, Michael C. Kearney2, Lynn Sorbara3, Sudhir Srivastava3, Stephen J. Meltzer4, Paul Pinsky3, Gary P. Kearney2. 1Beth Israel Deaconess Medical Ctr., Boston, MA; 2New England Baptist Hospital, Boston, MA; 3National Cancer Institute, NIH, Rockville, MD; 4Johns Hopkins University School of Medicine, Baltimore, MD Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4054/24 – Prognostic value of microRNAs expression in diffuse large B cell lymphoma
Michal Kushnir1, Meir Lahav2, Ron Ram2, Shlomit Gilad1, Meirav Zepeniuk1, Lahav Cohen1, Meital Ezagouri1, Osnat Baery2, Ofer Spilberg2, Meora Feinmesser2, Ranit Aharonov1, Gila Lithwick Yanai1. 1Rosetta Genomics, Rehovot, Israel; 2Rabin Medical Center, Petah Tikva, Israel Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4055/25 – Real-time quantitation of primary transcripts of microRNA genes
Yu Liang, Fangqi Hu, Emanuel Langit, Julia Lu, Pius Brzoska, Caifu Chen. Life Technology, Foster City, CA Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2313/25 – Role of ferritin dysregulation in human breast cancer cells
Svitlana I. Shpyleva1, Volodymyr P. Tryndyak1, Olga Kovalchuk2, Athena Starlard-Davenport1, Vasyl’ F. Chekhun3, Frederick A. Beland1, Igor P. Pogribny1. 1FDA-National Center for Toxicological Research, Jefferson, AR; 2University of Lethbridge, Lethbridge, AB, Canada; 3Institute of Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine Poster Session
PO.TB04.02. Epithelial-Mesenchymal Transition
Mon, Apr 19, 2:00 – 5:00 PM
Wed, Apr 21, 8:00 – 11:00 AM
4945/25 – Epigenetic silencing of microRNA-34b/c in human gastric cancer
Hiromu Suzuki1, Eiichiro Yamamoto2, Masanori Nojima3, Takashi Tokino4, Kohzoh Imai5, Minoru Toyota2, Yasuhisa Shinomura1. 1First Dept. of Internal Med., Sapporo Med. Univ., Sapporo, Japan; 2Dept. of Biochem., Sapporo Med. Univ., Sapporo, Japan; 3Dept. of Public Health, Sapporo Med. Univ., Sapporo, Japan; 4Dept. of Mol. Biol., Cancer Res. Inst., Sapporo Med. Univ., Sapporo, Japan; 5Sapporo Med. Univ., Sapporo, Japan Poster Session
PO.CB06.02. DNA Methylation 4
Wed, Apr 21, 8:00 – 11:00 AM
Tue, Apr 20, 9:00 AM – 12:00 PM
3050/26 – MicroRNA expression profiling of human Barrett’s carcinogenesis
Matteo Fassan1, Stefano Volinia2, Jeff Palatini2, Marco Pizzi1, Raffaele Baffa3, Roberto Clemente4, Christian Rizzetto4, Carlo M. Croce2, Giovanni Zaninotto5, Ermanno Ancona5, Massimo Rugge1. 1Department of Medical Diagnostic Sciences & Special Therapies, Pathology Unit, University of Padova, Padova, Italy; 2Comprehensive Cancer Center, Ohio State University, Columbus, OH; 3Department of Urology, Thomas Jefferson University, Philadelphia, PA; 4Istituto Oncologico Veneto – IOV-IRCCS, Padova, Italy; 5Department of Gastroenterological & Surgical Sciences, University of Padova, Padova, Italy Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3424/25 – Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of mRNA targets
Murray J. Matthew1, Harpreet K. Saini2, Stijn van Dongen2, Cei Abreu-Goodger2, Roger D. Palmer1, Balaji Muralidhar1, Mark R. Pett1, James C. Nicholson3, Anton J. Enright2, Nicholas Coleman1. 1MRC Cancer Cell Unit, Cambridge, United Kingdom; 2EMBL-European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom; 3Department of Paediatric Haematology and Oncology, Addenbrooke’s Hospital, Cambridge, United Kingdom Poster Session
PO.TB08.03. Pediatric Solid Tumors
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3020/26 – Identification of a subgroup with good prognosis of small-cell lung cancer by miRNA expression profiling
Takehiko Oba1, Hironori Ninomiya1, Sakae Okumura2, Makoto Nishio2, Mutsunori Fujiwara3, Yuichi Ishikawa1. 1Cancer Inst., Tokyo, Japan; 2Cancer Inst. Hospital, Tokyo, Japan; 3Japanese Red Cross Medical Center, Tokyo, Japan Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2044/25 – Altered microRNA expression induced by tumorigenic conazoles in mouse liver
Jeffrey A. Ross1, Carl F. Blackman1, Sheau-Fung Thai1, Zhiquan Li2, Michael Kohan1, Carlton P. Jones1, Tao Chen2. 1Environmental Protection Agency, Research Triangle Park, NC; 2National Center for Toxicological Research, U.S. FDA, Jefferson, AR Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2074/25 – Association of MnSOD and microRNA-301a regulation with inhibition of pancreatic ductal adenocarcinoma
Yan Li, Xuanshe Li, Yong Li, Russell E. Brown, Suzanne C. Schiffman, Robert C. Martin. Univ. of Louisville, Louisville, KY Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2104/25 – MicroRNA-101 promotes estrogen independent growth and confers tamoxifen resistance in ER positive breast cancer cells
Mohit Sachdeva1, Hailong Wu1, Peng Ru1, Larn Hwang2, Vuong Trieu2, Yin Yaun Mo1. 1SIUMED, Springfield, IL; 2Abraxis BioScience, Marina del Rey, CA Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2075/26 – MicroRNA-21 expression levels are accompanied by respective alterations in pdcd4 protein levels in non-small cell lung cancer
Ioanna S. Sourvinou1, Athina Markou1, Loukas Kaklamanis2, Emily G. Tsaroucha3, Iwata Ozaki4, Sachiko Matsuhashi4, Evi S. Lianidou1. 1University of Athens, Athens, Greece; 2Onassis Cardiac Surgery Center, Athens, Greece; 3“Sotiria” General Hospital for Chest Diseases, Athens, Greece; 4Saga University, Saga, Japan Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2045/26 – microRNA expression patterns associated with resistance to platinum-based chemotherapy in human cancer cell lines
Fan-Yu He1, Jang-Yang Chang2, Ching-Chuan Kuo2, Wen-Yu Pan2, Li-Tzong Chen2, Wen-Hui Weng1. 1Graduate Institute of Biotechnology, National Taipei University of Technology, Taipei, Taiwan; 2National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2105/26 – miR-125b promotes the tumor growth of prostate cancer cells in intact and castrated male nude mice
Xu-Bao Shi, Lingru Xue, Ralph W. deVere White. UC Davis Medical Ctr., Sacramento, CA Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3051/27 – mRNA and microRNA expression profiles integrated with drug sensitivities of the NCI-60 human cancer cell lines
Hongfang Liu1, Petula D’Andrade2, Stephanie Fulmer-Smentek2, Philip Lorenzi3, Kurt Kohn1, John Weinstein3, Yves G. Pommier1, William C. Reinhold1. 1National Cancer Inst., Bethesda, MD; 2Agilent Technologies, Santa Clara, CA; 3M. D. Anderson Cancer Center, Houston, TX Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3021/27 – MicroRNA expression profile of CT screening detected lung cancer
Gabriella Sozzi1, Mattia Boeri1, Luca Roz1, Davide Conte1, Piergiorgio Modena2, Federica Facchinetti1, Carlo Maria Croce3, Ugo Pastorino1. 1Fndn. IRCCS Inst. Nazionale dei Tumori, Milan, Italy; 2CRO, Aviano National Cancer Institute, Aviano, Italy; 3Ohio State University Cancer Center, Columbus, OH Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3606/26 – Gene and miRNA expression profiles in lung cancer cells cooperated with drug sensitivity to PKC inhibitor enzastaurin
Seike Masahiro, Tetsuya Okano, Tsuneo Shimokawa, Akihiko Gemma. Nippon Medical School, Tokyo, Japan Poster Session
PO.ET05.03. Pharmacogenomics and Personalized Medicine 3
Tue, Apr 20, 9:00 AM – 12:00 PM
Tue, Apr 20, 2:00 – 5:00 PM
4056/26 – MicroRNA-21 and -26a are novel markers to predict the sensitivity to chemotherapy in esophageal squamous cell carcinoma
Junji Kurashige, Masaaki Iwatsuki, Yukiharu Hiyoshi, Hidenobu Kamohara, Koichi Kinoshita, Seiya Saito, Nobutaka Sato, Ryuichi Karashima, Kotaro Hirashima, Masayuki Watanabe, Hideo Baba. Kumamoto University, Kumamoto, Japan Poster Session
PO.CB13.07. MicroRNA Therapeutics and Diagnostics
Tue, Apr 20, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3022/28 – The identification of novel senescence-associated miRNAs
Rut W. Klinger1, Darran P. O’Connor1, William M. Gallagher1, Igor B. Roninson2. 1University College Dublin, Dublin, Ireland; 2Ordway Cancer Center, Albany, NY Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2106/27 – Regulation of Rb1 and caspase 3/7 by miR-17-5p, miR-132/-212, and miR-337-3p: Oncogenic role of miRNAs in pancreatic cancer
Jong Kook Park1, Jinmai Jiang1, Yuriy Gusev2, Megan R. Lerner2, Daniel J. Brackett2, Thomas D. Schmittgen1. 1Ohio State University, Columbus, OH; 2University of Oklahoma Health Sciences Center, Oklahoma City, OK Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2046/27 – The hepatic miR-200/Zeb module is perturbed in the male Fischer rat following short term treatment with a carcinogenic dose of Phenobarbital
Costas Koufaris1, Jayne Wright2, Richard A. Currie2, Nigel J. Gooderham1. 1Imperial College London, London, United Kingdom; 2Syngenta, Jealott’s Hill, United Kingdom Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3052/28 – MicroRNA as a potential diagnostic marker for oral squamous cell carcinoma
Pawadee Lohavanichbutr1, John Houck1, Marni Stott-Miller1, David R. Doody1, Eduardo Mendez2, Neal Futran2, Melissa P. Upton2, Stephen M. Schwartz1, Chu Chen1. 1Fred Hutchinson Cancer Research Ctr., Seattle, WA; 2University of Washington, Seattle, WA Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2076/27 – Mammary stem cell-like miRNA expression and relation to cancer
Eylem Aydogdu1, Luisa Helguero2, Lars-Arne Haldosen3, Cecilia M. Williams1. 1University of Houston, Houston, TX; 2University of Aveiro, Aveiro, Portugal; 3Karolinska Institute, Stockholm, Sweden Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2107/28 – Deregulation of tumor suppressor miRNAs results in Six1 oncogene overexpression in pediatric and adult human cancers
J. Saadi Imam, Kalyan Buddavarapu, Jennifer S. Lee-Chang, Peter Hornsby, Yidong Chen, Kihoon Yoon, Manjeet Rao. UT Health Science Ctr. San Antonio, San Antonio, TX Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Sun, Apr 18, 2:00 – 5:00 PM
721/28 – An anaplastic lymphoma kinase antibody targets pancreatic allografts, prevents the progression of pancreatic cancer, and induces changes in microRNA expression
Joseph J. LaConti, Narayan Shivapurkar, Anju Preet, Sung E. Kim, Anna T. Riegel, Anton Wellstein. Lombardi Cancer Center, Georgetown University, Washington, DC Poster Session
PO.ET07.01. Targeting Receptors and Cell Surface Antigens
Sun, Apr 18, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3023/29 – MicroRNA expression profile in pancreatic cancer stem cells
Dawoon E. Jung1, Jing Wen1, Tae Yun Oh1, Si Young Song2. 1Brain Korea 21 Project for Medical Science, Seoul, Korea, Republic of; 2Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Republic of Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2077/28 – MicroRNA signature of hyperplastic enlarged lobular units (HELU) from patients with high risk of breast cancer
Sofie Nilsson1, Göran Landberg2. 1Lund University, Malmö, Sweden; 2Breakthrough Breast Cancer Research Unit, Manchester, United Kingdom Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3053/29 – Associations of microRNA-34a, -34b, and -34c expression with p53 status, diagnosis, and prognosis in colon and adenocarcinoma
Aaron J. Schetter1, Giang Huong Nguyen1, Jason E. Hawkes1, Jane J. Sohn1, Elise D. Bowman1, Suet Y. Leung2, Carlo M. Croce3, Curtis C. Harris1. 1National Cancer Institute, Bethesda, MD; 2University of Hong Kong, Pokfulam, Hong Kong; 3Ohio State University, Columbus, OH Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2047/28 – Expression of microRNAs in squamous cell carcinoma of human head and neck (HNSCC) and the esophagus (ESCC) and their regulation by hepatocyte growth factor
Sotai Kimura1, Seiji Naganuma1, Dai Susuki1, Naomi Kitamura2, Hiroshi Itoh1. 1University of Fukui Faculty of Medical Sciences, Fukui, Japan; 2Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology, Tokyo, Japan Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2108/29 – miR-1 is a putative tumor suppressor gene for urothelial bladder cancer.
Mark A. Wille, Gautam Jayram, Michael Large, Aimee Wiltz, Gary D. Steinberg, Victoria L. Robinson. Univ. of Chicago, Chicago, IL Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3054/30 – MicroRNA expression profile in cutaneous melanoma: miR-17-92 cluster is a progression and prognostic marker
Donghwa Kim, Jianjun Zhao, William Kong, Keiran S. Smalley, Jane L. Messina, Jeffrey S. Weber, Jin Q. Cheng. H. Lee Moffitt Cancer Ctr. & Res. Inst., Tampa, FL Poster Session
PO.CB13.05. MicroRNA Profiling in Cancer 2
Tue, Apr 20, 9:00 AM – 12:00 PM
Wed, Apr 21, 8:00 – 11:00 AM
5020/29 – Role of LIN28 in aggressive breast cancers lacking REST
Kearney T.W. Gunsalus, Matthew P. Wagoner, Wyatt B. Potter, Barry Schoenike, Avtar Roopra. University of Wisconsin-Madison, Madison, WI Poster Session
PO.CB04.08. Novel Tumor Suppressor Genes 2
Wed, Apr 21, 8:00 – 11:00 AM
Mon, Apr 19, 2:00 – 5:00 PM
2078/29 – Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development
Masami Tanaka1, Akihiko Tsuchida1, Masatoshi Shigoka1, Tetsuya Aoki1, Tomoki Takashina1, Masakatsu Takanashi1, Yoshiki Murakami2, Masahiko Kuroda1. 1Tokyo Medical Univ., Tokyo, Japan; 2Kyoto Univ., Kyoto, Japan Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Tue, Apr 20, 9:00 AM – 12:00 PM
3024/30 – miRNA expression profiles in sarcomas
Princy Francis1, Jeffrey Knight1, Sven Bilke1, Sean Davis1, Yuelin Zhu1, Robert L. Walker1, Marbin Pineda1, Hui Wang2, Laurakay Bruhn2, Paul S. Meltzer1. 1National Cancer Institute, National Institutes of Health, Bethesda, MD; 2Agilent Technologies, Inc., Agilent Laboratories, Santa Clara, CA Poster Session
PO.CB13.04. MicroRNA Profiling in Cancer 1
Tue, Apr 20, 9:00 AM – 12:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2048/29 – microRNA regulation of tissue factor expression in breast cancer cells
Xiao-Xi Zhang1, Haijun Yu1, Jessica R. Lou1, Jie Zheng1, Narcis-Ioan Popescu2, Florea Lupu2, Wei-Qun Ding1. 1Univ. of Oklahoma Health Sciences Ctr., Oklahoma City, OK; 2Oklahoma Medical Research Foundation, Oklahoma City, OK Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2049/30 – Post transcriptional regulation of RhoB expression
Valerie Glorian1, Gerard Maillot1, Sophie Poles2, Gilles Favre1, Stephan Vagner3. 1Institut Claudius Regaud, Toulouse, France; 2RITC Foundation, Toulouse, France; 3INSERM, Toulouse, France Poster Session
PO.CB13.01. MicroRNA-Mediated Regulation of Cancer Biology 2
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2079/30 – Estrogen receptor alpha expression with miR-206 trans-acting regulation roles in breast cancer cell lines
Young Eun Choi, Junkyu Song, Yong Hwa Jo, Hyun Mi Park, Kyung-Sik Yoon, Department of Biochemistry and Molecular Biology(BK21 project), MRC for Bioreaction to ROS and Bio. Graduate School of Medicine, Kyung Hee, Seoul, Korea, Republic of Poster Session
PO.CB13.02. MicroRNA-Mediated Regulation of Cancer Biology 3
Mon, Apr 19, 2:00 – 5:00 PM
Mon, Apr 19, 2:00 – 5:00 PM
2109/30 – Mir-125b confers the resistance of cancer cells to Taxol through suppression of Bak1
Ming Zhou1, Yuhua Zhao1, Yan Ding1, Hao Liu1, Zixing Liu1, Yaguang Xi1, Wei Xiong2, Guiyuan Li2, Jianrong Lu3, Oystein Fodstad4, Adam I. Riker5, Ming Tan1. 1Mitchell Cancer Institue, Univ. of South Alabama, Mobile, AL; 2Cancer Research Institute, Central South University, Changsha, China; 3Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL; 4Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway; 5Ochsner Cancer Institute, Ochsner Health System, New Orleans, LA Poster Session
PO.CB13.03. MicroRNAs as Tumor Suppressor Genes and Oncogenes
Mon, Apr 19, 2:00 – 5:00 PM

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