The identification of microRNA biomarkers in the cerebrospinal fluid may become an important method for the diagnosis of primary central nervous system disorders.
Researchers have identified and quantified microRNAs in cerebrospinal fluid samples taken from patients with primary central nervous system lymphomas and as well as patients with a variety of neurologic disorders, including inflammatory disorders1.
The identification of microRNA biomarkers in CSF was first reported back in 20082.
1. Baraniskin A, Kuhnhenn J, Schlegel U, Chan A, Deckert M, Gold R, Maghnouj A, Zöllner H, Reinacher-Schick A, Schmiegel W, Hahn SA, Schroers R. (2011) Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system. Blood [Epub ahead of print]. [abstract]
2. Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B, Kelnar K, Kemppainen J, Brown D, Chen C, Prinjha RK, Richardson JC, Saunders AM, Roses AD, Richards CA. (2008) Identification of miRNA changes in Alzheimer’s disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 14(1), 27-41. [abstract]