MicroRNA Clusters Implicated in Chronic Lymphocytic Leukemia

from MedPage Today  By Crystal Phend

A potential clue — involving MicroRNA clusters — may help unlock mysteries surrounding the development, clinical course, and perhaps the prognosis of chronic lymphocytic leukemia (CLL), researchers report.

Several microRNA clusters appeared to work in a feedback circuit with the tumor protein p53 (TP53) and other genes with well-known prognostic significance in CLL, George A. Calin, MD, PhD, of the University of Texas MD Anderson Cancer Center in Houston, and colleagues found in a series of experiments.

This circuitry “likely underlies the pathogenesis and natural history of a major subset of human CLL,” they wrote in the Jan. 5 issue of the Journal of the American Medical Association.

Fabbri M, et al (2011) Association of a nicroRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia JAMA 305, 59-67. [article]

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Tagged as: chronic lymphocytic leukemia, george calin, MD Anderson Cancer Center, microrna, mirna, p53, tp53