When you consider that microRNAs have now been linked to almost every biological function, how is it possible that the detection of microRNAs had escaped scientists for so long? For example, a single microRNA, miR-206 with functions that range from estrogen regulation to suppression of breast cancer metastasis to regulation of neuromuscular signaling. Amazing!
- Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN. (2009) MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 326(5959), 1549-554 [abstract]
- Song G, Wang L. (2009) Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanism. PLoS One 4(9), e6880. [abstract]
- Klinge CM. (2009) Estrogen Regulation of MicroRNA Expression. Curr Genomics 10(3), 169-83. [abstract]
- Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451(7175), 147-52. [abstract]