microRNA of the week: microRNA-206

by Chris on February 12, 2010

in Technical Article

When you consider that microRNAs have now been linked to almost every biological function, how is it possible that the detection of microRNAs had escaped scientists for so long? For example, a single microRNA, miR-206 with functions that range from estrogen regulation to suppression of breast cancer metastasis to regulation of neuromuscular signaling. Amazing!

  1. Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN.  (2009) MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in miceScience 326(5959), 1549-554 [abstract]
  2. Song G, Wang L. (2009) Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanismPLoS One 4(9), e6880.  [abstract]
  3. Klinge CM.  (2009) Estrogen Regulation of MicroRNA Expression.  Curr Genomics 10(3), 169-83.  [abstract]
  4. Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451(7175), 147-52.  [abstract]

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christoph February 17, 2010 at 10:05 am

And another one – this just came in:
Muscle-specific miRNA -206 was found to be a key member of network of miRNAs that help to define the extraocular muscle (EOM) group by regulating post-transcriptional expression of genes in structure, signaling, metabolism, angiogenesis, myogenesis and regeneration in EOM. The EOMs are a unique group of muscles that are anatomically and physiologically distinct from other muscles.

Zeiger U, Khurana TS. (2010) Distinctive Patterns of MicroRNA Expression in Extraocular Muscles. Physiol Genomics [Epub ahead of print].
http://www.ncbi.nlm.nih.gov/pubmed/20145202?dopt=Abstract

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