Steatohepatitis is a type of liver disease, characterized by inflammation and fat accumulation in the liver, which can lead to cirrhosis. Steatohepatitis is frequently seen in alcoholics and people with diabetes and/or obesity and alcoholic and nonalcoholic steatohepatitis are leading causes of liver diseases worldwide. Researchers at UMASS Medical School used microarray to examine the microRNA expression profiles in mouse models of steatohepatitis of both alcoholic and non-alcoholic etiology1. The data they present about the baseline status of the microRNA profile in normal liver and upon development of steatohepatitis facilitate better understanding of this disease and opens new avenues for research its pathophysiology.
- Dolganiuc A, Petrasek J, Kodys K, Catalano D, Mandrekar P, Velayudham A, Szabo G. (2009) MicroRNA Expression Profile in Lieber-DeCarli Diet-Induced Alcoholic and Methionine Choline Deficient Diet-Induced Nonalcoholic Steatohepatitis Models in Mice. Alcohol Clin Exp Res 33(10), 1704-10. [abstract]