MicroRNAs have emerged as promising biomarkers of organ damage including injury of the liver. In this study the new generation of high-throughput sequencing technology was applied to detect circulating miRNAs in serum from patients with accidental acetaminophen overdose and identified a set of 33 known miRNAs and 3 novel miRNA-like small RNAs that are functionally associated with liver-specific biological processes and relevant to acetaminophen toxic mechanisms. The study suggests a profile of circulating miRNAs in human serum that might provide additional biomarker candidates for drug-induced liver injury and possibly adds mechanistic information relevant to liver injury.
For the full article:
Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC. Application of High-Throughput Sequencing to Circulating microRNAs Reveals Novel Biomarkers for Drug-induced Liver Injury. Toxicol Sci. 2014 Oct 29. pii: kfu232. [Epub ahead of print] PubMed PMID: 25359176.
Subscribe to the miRNA blog
Thank you for subscribing.
Something went wrong.