cancer

MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines

September 23, 2011

Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive cancers in women. Advanced stage diagnosis and chemo/radio-resistance is a major obstacle in treating advanced ovarian cancer. The most commonly employed chemotherapeutic drug for [...]

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Small molecules shed light on cancer therapies

August 22, 2011

Patients suffering from an aggressive brain cancer will benefit from the results of a University of Illinois study that could advance the development of targeted gene therapies and improve prognosis. “We have advanced the understanding of the role of microRNAs on glioblastoma multiforme, a deadly brain cancer, by studying the networks between the microRNAs and [...]

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Rosetta Genomics and UC Davis Researchers to Develop and Validate microRNA Biomarker to Predict Response to Neoadjuvant Chemotherapy in Bladder Cancer

June 28, 2011

PHILADELPHIA and REHOVOT, Israel, June 28, 2011 /PRNewswire/ – Rosetta Genomics (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostic tests, announces it has entered into a collaboration with the University of California,  Davis (“UC Davis” or the “University”) to develop and validate a microRNA profile for muscle-invasive bladder cancer (MI-BC) that is [...]

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New Study in PNAS Links Inflammation and Cancer

April 21, 2011

Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25 percent of all cancers. This study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) found that inflammation stimulates [...]

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A microRNA network controlling cancer cells survival and chemosensitivity

January 12, 2011

A central challenge in human cancer therapy is the identification of pathways that control tumor cell survival and chemosensitivity in the absence of functional p53. In a new paper, Benjamin ORY and colleagues from the Leif Ellisen lab at the MGH and Harvard Med School Cancer center identified a new and physiologically important microRNA-related mechanism [...]

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microRNAs as Biomarkers in Plasma

October 20, 2010

MicroRNAs (miRNAs) are small non-coding RNAs found in eukaryotic organisms that regulate gene expression. Dismissed as “junk” until about a decade ago, it is now widely accepted that they play an important functional role in a wide array of cellular processes. MiRNAs regulate gene expression by targeting individual or multiple messenger RNAs (mRNAs). Perfect or [...]

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microRNAs Associated with Cancer

October 12, 2010

Found this concise table of human microRNAs relating to cancer in a recent review article1.  Anyone care to add to this based on their own research? Cancer Type Human microRNA Potential Function Breast Cancer miR-21, miR-125b; miR126, miR-206, miR-335 OncomiR; Metastasis Suppressor Colon Cancer miR-21; miR-34a OncomiR; Tumor Suppressor Lung Cancer miR-21, miR17-92 cluster, miR-106b/93/25 [...]

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microRNA Inhibitor Fights Cancer

September 27, 2010

“What is really exciting about this research is it is the first time that anyone has blocked the growth of a primary tumour by the simple delivery of a microRNA inhibitor.” Dr Susan Woods – QIMR Researchers from the Queensland Institute of Medical Research, the Garvan Institute of Medical Research and the University of California-San [...]

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microRNA Abstracts – AACR Meeting 2010

April 12, 2010

Presentation  Authors Session Mon, Apr 19, 2:00 – 5:00 PM 2080/1 – miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma Mayuko Furuta1, Ken-ichi Kozaki2, Shinji Tanaka2, Shigeki Arii2, Issei Imoto2, Johji Inazawa1. 1Tokyo Medical and Dental University & GCOE program for IHMSTBD, Tokyo, Japan; 2Tokyo Medical and Dental University, Tokyo, Japan Poster [...]

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microRNA of the Week: microRNA-200 Family

March 26, 2010

The miR-200 family is a particularly nasty group of microRNAs. Changes in miR-200 family levels have been associated with enhanced tumorigenesis and significantly correlated with decreased survival.  miR-200 family members are associated with resistance to several chemotherapy drugs: docetaxel  in non-small cell cancer cells1, cisplatin in breast cancer cells2, and gemcitabine in cholangiocarcinoma cells. It [...]

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