inflammation

New Study in PNAS Links Inflammation and Cancer

by Chris on April 21, 2011

Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25 percent of all cancers. This study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) found that inflammation stimulates a rise in levels of a molecule called microRNA-155 (miR-155).  (read the entire story… )

[Ohio State Press Release]

Tili E, Michaille JJ, Wernicke D, Alder H, Costinean S, Volinia S, Croce CM. (2011) Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer. Proc Natl Acad Sci USA 108(12), 4908-13. [article]

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HSV Linked to Alzheimer’s

by Chris on November 11, 2009

Researchers at the LSU Neuroscience Center have discovered a role for miRNA-146a in the evasion of Herpes simplex virus type-1 (HSV-1) from the complement system (a major first-line host defense mechanism), and the activation of key elements of the arachidonic acid cascade known to contribute to Alzheimer-type neuropathological change.

MicroRNA microarray revealed that human primary neural cells infected with HSV-1 (17syn +) showed upregulation of miRNA-146a, a brain-enriched microRNA that is associated with proinflammatory signaling in stressed brain cells and Alzheimer’s disease.

Hill JM, Zhao Y, Clement C, Neumann DM, Lukiw WJ.  (2009) HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling. Neuroreport 20(16), 1500-505.  [abstract]

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