microrna-206

microRNA of the week: microRNA-206

by Chris on February 12, 2010

in Technical Article

When you consider that microRNAs have now been linked to almost every biological function, how is it possible that the detection of microRNAs had escaped scientists for so long? For example, a single microRNA, miR-206 with functions that range from estrogen regulation to suppression of breast cancer metastasis to regulation of neuromuscular signaling. Amazing!

  1. Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN.  (2009) MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in miceScience 326(5959), 1549-554 [abstract]
  2. Song G, Wang L. (2009) Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanismPLoS One 4(9), e6880.  [abstract]
  3. Klinge CM.  (2009) Estrogen Regulation of MicroRNA Expression.  Curr Genomics 10(3), 169-83.  [abstract]
  4. Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451(7175), 147-52.  [abstract]

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Researchers at the University of Texas Southwestern Medical Center, Dallas have identified miR-206 as a modifier of amyotrophic lateral sclerosis (ALS) pathogenesis  and define a role for a microRNA (miR-206) in reinnervating the neuromuscular junction after injury and improving survival in a mouse model of the disease. The findings provide insight into the molecular basis of neuromuscular junction plasticity and also into determinants of rates of disease progression in motor neuron disease and suggest opportunities for intervention through the modulation of miR-206.

Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN.  (2009) MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice.  Science 326(5959), 1549-54 [abstract]

Additionally, a perspective on these important findings was published in the same issue of Science.

Brown, RH. (2009) A Reinnervating  MicroRNA. Science 326(5959), 1494-95. [abstract]

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