microrna microarray

UNLOCKING THE SECRETS OF microRNA

December 2, 2009

By Anne Harding Microarrays are a vital tool in research on microRNAs, the tiny noncoding stretches of genetic material that regulate messenger RNA. They can’t be beat for reading the microRNA “fingerprints” unique to disease states. But keeping up with this super hot field is a challenge for commercial microarray makers, and competition is fierce.  […]

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HSV Linked to Alzheimer’s

November 11, 2009

Researchers at the LSU Neuroscience Center have discovered a role for miRNA-146a in the evasion of Herpes simplex virus type-1 (HSV-1) from the complement system (a major first-line host defense mechanism), and the activation of key elements of the arachidonic acid cascade known to contribute to Alzheimer-type neuropathological change. MicroRNA microarray revealed that human primary neural […]

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MicroRNAs Regulate Dendritic Spine Morphogenesis

November 9, 2009

Researchers at Heidelberg University used a combination of expression profiling of miRNAs and subsequent functional inhibitory screening in primary hippocampal neurons to identify miRNAs in the synaptodendritic compartment that function during synaptic development. MicroRNA microarrays identified ten mature miRNAs that were enriched and four mature miRNAs that were strongly depleted in synaptosomes compared with whole […]

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microRNA Target Identification in Mammals

October 7, 2009

Identifying the target mRNA against miRNA is essential to understanding cellular regulatory networks. However, due to the low complementarity between a miRNA and its target mRNAs in mammals, identification of mammalian miRNA targets has been a challenge and only a few have been reported to date. Researchers at the Genome Research Laboratories, Wako Pure Chemical […]

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