microrna

Hepatitis C virus hijacks liver microRNA

January 3, 2012

Stabilization of hepatitis C virus RNA by an Ago2–miR-122 complex MicroRNAs regulate eukaryotic gene expression by binding to regions of imperfect complementarity in mRNAs, typically in the 3′ UTR, recruiting an Argonaute (Ago) protein complex that usually results in translational repression or destabilization of the target RNA. The translation and decay of mRNAs are closely [...]

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Regulus Therapeutics Initiates an Orphan and Rare Disease microRNA Therapeutic Effort in Brain Cancer

December 12, 2011

-Regulus, Accelerate Brain Cancer Cure (ABC2) and Samsung Medical Center to Advance microRNA Therapeutics for Glioblastoma – LA JOLLA, Calif., Dec. 12, 2011 /PRNewswire/ – Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today announced the initiation of a new discovery effort in microRNA therapeutics for the treatment [...]

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Rosetta Genomics Announces New York State Approval for miRview mets²

December 9, 2011

Proprietary microRNA Diagnostic for Identification of Cancer of Unknown Primary Now Available in All 50 U.S. States PHILADELPHIA, PA and REHOVOT, ISRAEL–(Marketwire – Dec 9, 2011) – Rosetta Genomics, Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, announced that the New York State Department of Health has approved miRview® mets² for [...]

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miRNEST database: an integrative approach in microRNA search and annotation

December 8, 2011

Despite accumulating data on animal and plant microRNAs and their functions, existing public miRNA resources usually collect miRNAs from a very limited number of species. A lot of microRNAs, including those from model organisms, remain undiscovered. As a result there is a continuous need to search for new microRNAs. Izabela Makałowska’s Laboratory of Evolutionary Genomics [...]

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MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates

December 8, 2011

How the human brain and human cognitive abilities evolved in less than six million years has long puzzled scientists. A new study conducted by scientists in China and Germany, and published December 6 in the online, open-access journal PLoS Biology, now provides a possible explanation by showing that activity levels of genes in the human [...]

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Plasma Components Affect Accuracy of Circulating Cancer-Related MicroRNA Quantitation

December 7, 2011

New protocols improve detection of microRNAs for diagnosis Philadelphia, PA, — MicroRNAs (miRNAs) that regulate processes including fertilization, development, and aging show promise as biomarkers of disease. They can be collected from routinely collected fluids such as blood, saliva, and urine. However, a number of factors can interfere with the accuracy of miRNA tests. In [...]

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MiraDx Highlights Breakthrough Publication Describing a Marker for Resistance to Platinum Treatment in Ovarian Cancer

December 7, 2011

NEW HAVEN, Conn., Dec. 7, 2011 /PRNewswire/ – Mira Dx® today notes the publication of breakthrough research showing that the KRAS-variant acts as a biomarker of poor survival and worse response to treatment for patients with ovarian cancer(1). Ovarian cancer patients with the KRAS-variant are twice as likely to die of their ovarian cancer, and three times [...]

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OvaGene Oncology Collaborates With Moffitt Cancer Center to Develop and Commercialize microRNAs Associated With Chemotherapeutic Drug Response

December 5, 2011

IRVINE, Calif., Dec. 5, 2011 /PRNewswire/ — OvaGene Oncology Inc., a molecular diagnostics company specializing in the development and commercialization of personalized gene-based diagnostics for gynecologic cancer, announced today that it has completed a major Licensing and Collaboration Agreement with The Moffitt Cancer Center, the only National Cancer Institute (NCI) Comprehensive Cancer Center in Florida. [...]

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Tiny genetic variation can predict ovarian cancer outcome

December 5, 2011

Yale Cancer Center researchers have shown that a tiny genetic variation predicts chances of survival and response to treatment for patients with ovarian cancer. The findings, published in the journal Oncogene, provide new insights into the biology of a new class of cancer marker and suggest a genetic test may help guide the treatment of [...]

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MicroRNAs and Vascular(dys)function

November 28, 2011

Elsevier recently published a special issue of  “Vascular Pharmacology” covering microRNAs: MicroRNAs and Vascular(dys)function, edited by Costanza Emanueli. Volume 55, Issue 4, Pages e1-e4, 59-118 (October 2011) For more details see: http://www.sciencedirect.com/science/journal/15371891/55/4 Incoming search terms for this article:vascular mirna

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