mirna

Rosetta Green Has Successfully Improved Plant Growth Under Intermittent Irrigation With Seawater

January 10, 2012

The experiment tested a specific microRNA gene that was identified in corn and soybean, and confirmed the potential to develop plants capable of withstanding intermittent irrigation with seawater and growth in high salinity soils During the experiment, plants were intermittently irrigated with salt water with three times the salinity level of seawater Rosetta Green has [...]

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Silence Therapeutics Signs Collaboration with miRagen Therapeutics to Evaluate Delivery of Novel microRNA-based Therapeutics

January 9, 2012

LONDON, January 9, 2012/PRNewswire-FirstCall/ – – Third collaboration to investigate the potential application of Silence’s proprietary RNAi delivery technologies in the development of novel microRNA-based therapeutics Silence Therapeutics plc (AIM: SLN) (“Silence”), a leading RNA interference (RNAi) therapeutics company, announces that it has signed an agreement with miRagen Therapeutics, Inc. (“miRagen”), to assess the delivery [...]

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RNA Interference – Video Animation

January 6, 2012

This is an amazing video animation from Nature Reviews Genetics! This animation introduces the principles of RNAi involving small interfering RNAs (siRNAs) and microRNAs (miRNAs). It takes you on an audio-visual journey through the steps of gene expression and shows you an up-to-date view of how RNAi can silence specific mRNAs in the cytoplasm. There [...]

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Hepatitis C virus hijacks liver microRNA

January 3, 2012

Stabilization of hepatitis C virus RNA by an Ago2–miR-122 complex MicroRNAs regulate eukaryotic gene expression by binding to regions of imperfect complementarity in mRNAs, typically in the 3′ UTR, recruiting an Argonaute (Ago) protein complex that usually results in translational repression or destabilization of the target RNA. The translation and decay of mRNAs are closely [...]

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Regulus Therapeutics Initiates an Orphan and Rare Disease microRNA Therapeutic Effort in Brain Cancer

December 12, 2011

-Regulus, Accelerate Brain Cancer Cure (ABC2) and Samsung Medical Center to Advance microRNA Therapeutics for Glioblastoma – LA JOLLA, Calif., Dec. 12, 2011 /PRNewswire/ – Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today announced the initiation of a new discovery effort in microRNA therapeutics for the treatment [...]

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Rosetta Genomics Announces New York State Approval for miRview mets²

December 9, 2011

Proprietary microRNA Diagnostic for Identification of Cancer of Unknown Primary Now Available in All 50 U.S. States PHILADELPHIA, PA and REHOVOT, ISRAEL–(Marketwire – Dec 9, 2011) – Rosetta Genomics, Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, announced that the New York State Department of Health has approved miRview® mets² for [...]

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miRNEST database: an integrative approach in microRNA search and annotation

December 8, 2011

Despite accumulating data on animal and plant microRNAs and their functions, existing public miRNA resources usually collect miRNAs from a very limited number of species. A lot of microRNAs, including those from model organisms, remain undiscovered. As a result there is a continuous need to search for new microRNAs. Izabela Makałowska’s Laboratory of Evolutionary Genomics [...]

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MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates

December 8, 2011

How the human brain and human cognitive abilities evolved in less than six million years has long puzzled scientists. A new study conducted by scientists in China and Germany, and published December 6 in the online, open-access journal PLoS Biology, now provides a possible explanation by showing that activity levels of genes in the human [...]

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Plasma Components Affect Accuracy of Circulating Cancer-Related MicroRNA Quantitation

December 7, 2011

New protocols improve detection of microRNAs for diagnosis Philadelphia, PA, — MicroRNAs (miRNAs) that regulate processes including fertilization, development, and aging show promise as biomarkers of disease. They can be collected from routinely collected fluids such as blood, saliva, and urine. However, a number of factors can interfere with the accuracy of miRNA tests. In [...]

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MiraDx Highlights Breakthrough Publication Describing a Marker for Resistance to Platinum Treatment in Ovarian Cancer

December 7, 2011

NEW HAVEN, Conn., Dec. 7, 2011 /PRNewswire/ – Mira Dx® today notes the publication of breakthrough research showing that the KRAS-variant acts as a biomarker of poor survival and worse response to treatment for patients with ovarian cancer(1). Ovarian cancer patients with the KRAS-variant are twice as likely to die of their ovarian cancer, and three times [...]

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