regulus therapeutics logoLA JOLLA, Calif., Nov. 12, 2015 /PRNewswire/ — Regulus Therapeutics Inc. (NASDAQ:RGLS), a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs (miR), today announced that the U.S. Patent and Trademark Office (“USPTO”) has granted patents related to Regulus’ most advanced microRNA therapeutics, RG-101, the company’s wholly-owned, GalNAc-conjugated anti-miR-122 being developed to treat HCV, and RG-012, an anti-miR-21 being developed to treat Alport syndrome.

  • RG-101 – claims of the patent, owned solely by Regulus, cover the unconjugated anti-miR-122 component of RG-101, the GalNAc-conjugated anti-miR-122 of RG-101, and pharmaceutical compositions comprising either the unconjugated or conjugated compounds. Regulus’ patent portfolio related to RG-101 covers compositions and methods of use for the treatment of HCV in the United States and numerous foreign jurisdictions.
  • RG-012 – claims of the patents, owned solely by Regulus, cover the anti-miR-21 component of RG-012, as well as pharmaceutical compositions and methods of treatment of [click to continue…]


Expands the Company’s Patent Portfolio in Oncology Therapeutics

Rosetta Genomics LogoPRINCETON, NJ and REHOVOT, ISRAEL–(Marketwired – Nov 7, 2013) – Rosetta Genomics Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, announces receipt of a Notice of Allowance from the U.S. Patent and Trademark Office (USPTO) related to U.S. Patent Application No. 13/481,105 titled “Targeting microRNAs for the Treatment of Liver Cancer.”

This allowance is for a therapeutic patent that protects a method for treating hepatocellular carcinoma (HCC), or liver cancer, and covers the administration of a compound comprising a modified oligonucleotide that is an anti-miR-222. In addition, various modifications of the nucleotide are claimed. There is an additional claim which refers to the reduction of the levels of serum alpha-fetoprotein or serum des-gamma-carboxyprothrombin in the subject to be treated.

“HCC is the fifth most common cancer in the world and the third leading cause of cancer deaths. Because standard chemotherapy usually has no beneficial outcome on HCC patients, there is significant need for new therapeutic modalities and novel therapeutic [click to continue…]


COLUMBUS, Ohio, and NEW YORK, Sept. 26, 2013 /PRNewswire/ — The Ohio State University today announced the signing of an exclusive world-wide agreement with Microlin Bio Inc., licensing a large portfolio of Ohio State’s groundbreaking cancer discoveries. The portfolio includes nearly 100 issued and pending microRNA patents that could lead to entirely new, more effective and more targeted ways to diagnose and treat prostate, ovarian, colon and lung cancers. Additionally, Microlin Bio Inc. has licensed a novel nucleic acid delivery technology to deliver these transformational therapies to cancer cells.

These technologies, years in the making, were developed by The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) researcher Carlo Croce, M.D., The Ohio State University College of Pharmacy researcher Robert Lee, Ph.D., and collaborators from the National Cancer Institute with the National Institutes of Health.

Just over 10 years ago, Croce was the first in the world to link small cellular molecules called microRNA to cancer. MicroRNAs are now known to play a pivotal role in the growth and spread of many [click to continue…]


Award Strengthens Growing Portfolio of microRNAs in Viral Infection

PHILADELPHIA and REHOVOT, Israel, March 18, 2013 /PRNewswire/ — Rosetta Genomics Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, announces receipt of a Notice of Allowance from the U.S. Patent Office related to U.S. Patent Application No. 12/517,760 entitled “Nucleic Acids Involved in Viral Infection.”

The allowed claims include a method of reducing the amount of virus replication in a target cell infected with the virus by introducing into the target cell an effective amount of miR-210, its variants or its precursor.

“We are delighted to add this new patent to our expanding intellectual property portfolio of microRNAs in viral infection.  This newly granted patent further solidifies our dominant patent position in microRNAs and opens up other disease states where microRNAs may be of great benefit.  Many of the current viral therapeutics suffer from low efficacy, toxicity and induction [click to continue…]


Protects Composition of Matter and Sequencing Variants Core to its microRNA-based Molecular Diagnostics

Rosetta Genomics LogoNOTE:  hsa-miR-29c* mentioned bellow is the old name for hsa-miR-29c-5p.

PHILADELPHIA and REHOVOT, Israel, Feb. 14, 2013 /PRNewswire/ — Rosetta Genomics Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, today announced that the Company has received  two notices of allowance from the U.S. Patent and Trademark Office (“USPTO”) for Patent Applications 12/661,041 and 12/850,091.

The allowed claims of 12/661,041, entitled “microRNAs and Uses Thereof,” cover the composition of matter for miR-29c*, as well as sequence variants (90% identical thereto), a vector and a probe comprising the same.  miR-29c* is a core element in the Company’s lead commercial product, miRview® mets2 diagnostic assay for the identification of the tumor of origin in Cancer of Unknown and Uncertain Primary (“CUP”).

The allowed claims of 12/850,091, entitled “Viral and Viral Associated MiRNAs and Uses Thereof,” cover the composition of matter for herpes simplex virus 1 miR-H3, miR-H4 and miR-H5, as well as [click to continue…]


Rosetta Genomics Announces Issuance of Additional U.S. Patent

May 9, 2011

Strengthens its Broad and Deep microRNA Intellectual Property for microRNA-based Diagnostics PHILADELPHIA and REHOVOT, Israel, May 9, 2011 /PRNewswire/ — Rosetta Genomics (NASDAQ: ROSG) today announced that the United States Patent and Trademark Office (USPTO) has issued U.S. Patent No. 7,943,745, which is related to human hsa-miR-497 and its variants and covers the composition of […]

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Regulus, Alnylam and Isis Announce U.S. Allowance of Tuschl III Patent Application Covering miR-21

January 25, 2010

Business Wire 1/25/09 The newly allowed claims cover miR-21, a microRNA that has been linked to a variety of diseases, including cancer, fibrosis, and heart disease. The claims additionally encompass single-stranded and double-stranded antisense compounds complementary to miR-21. The allowance of this second Tuschl III patent in the U.S. extends the scope of this patent […]

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