An emerging major challenge is the interpretation of the genome-scale miRNA datasets, including those derived from microarray and deep-sequencing. It is interesting and important to know the common rules or patterns behind a list of miRNAs, (i.e. the deregulated miRNAs resulted from an experiment of miRNA microarray or deep-sequencing). TAM is a tool for annotations that can efficiently identify meaningful categories for given miRNAs. In addition, TAM can be used to identify novel miRNA biomarkers.
TAM tool, source codes, and miRNA category data are freely available at http://cmbi.bjmu.edu.cn/tam
Lu M, Shi B, Wang J, Cao Q, Cui Q. (2010) TAM: A method for enrichment and depletion analysis of a microRNA category in a list of microRNAs. BMC Bioinformatics 11, 419. [abstract]