The incredible enthusiasm for miRNAs as a novel class of functional regulators of tissue maintenance and stress responses demands for appropriate and reliable research tools. This review summarizes many of the currently available basic tools and describes the most widely used approaches for miRNA research to date. Although it will be the combination of several validated research methods that will enable researchers to validate the relevance or contribution of a miRNA to a certain phenotype, some caution should be taken to circumvent erroneous interpretation of data.
van Rooij E. (2011) The Art of MicroRNA Research. Circ Res 108(2), 219-34. [article]