microRNA – a Biomarker for Type II Diabetes

DALLAS, Sept. 17 /PRNewswire-USNewswire/ — For the first time, scientists have found that blood levels of some ribonucleic acids (microRNAs) are different among people with type 2 diabetes and those who subsequently develop the disease compared to healthy controls, according to research reported in Circulation Research: Journal of the American Heart Association1.

Changes in five specific microRNAs correctly identified most cases of diabetes and even some patients who later developed diabetes, while normal levels of these microRNAs classified 92 percent of healthy controls.

Of the microRNAs studied, microRNA 126, which promotes blood vessel growth, was among the most predictive of diabetes.

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  1. Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, Shah A, Willeit J, Mayr M. (2010) Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes. Circ Res 107(6), 810-17. [abstract]

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