Leave a comment naming your favorite microRNA and a quick explanation of why its your favorite.
The winner will be featured as the “microRNA of the week” in an upcoming post.
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My favorite microRNA has to be cel-let-7 because its the one that started it all!
Supposed to be miR-21 and miR-34a, interesting counterparts of carcinogenesis.
My favorite microRNA is miR-168
miR-168 is known to regulate AGO1 which is involved in the miRNA biogenesis
at the moment my favourite miR is miR-328, since up to now it is the only one that was found to upregulate a proteinexpression
My favourite miR is let-7a. The reason is that it is expressed in proliferating cells, but it is inactive (probably uridinylated, as by northern blots showing a higher MW). When the differentiation occurs, it is apparently at the same level or decreased, but it is active since its target genes are downregulated.
mmu-miR-124, because it seems to be the simplest of them all on the surface of it (seemingly just maintains nervous tissue identity). But with recent papers from groups of Kandel, Bartel and Miska – nobody deeply understands it’s role! And it is a good example of how little we know about non-coding RNAs..
I vote miR-9 for carcinogenesis implication.
miR-33 because it gives only 3 hits on PubMed and no target has been validated so far, although it’s so clear where to look for… 🙂
hsa-miR-122, because it’s a liver-specific miR and it accounts of 70% of hepatic microRNA. This is a very special microRNA.
hsa-miR-125b, ’cause I am working..:)