MicroRNAs: A potential new frontier for medicine
In this special issue of Translational Research, several articles review the complex role for miRNAs in the pathobiology of multiple organ systems that include the lung, heart, kidney, liver, skeletal muscle, and immune system. The reviews, as an ensemble, touch on several themes in our current understanding of microRNAs, and these themes are the subject of this commentary. An essential role for the control of posttranscriptional gene expression is underscored by the affects of knocking out key regulators of miRNA biogenesis. The adaptive capacity of the miRNA machinery to modify the protein profile of the transcriptome, in response to environmental cues, is evident in the genetic organization and variability of their loci as well as in the elaborate feedback systems that are used or co-opted in diseases such as cancer, fibrosis, and sepsis, as well as autoimmune disease. Current efforts to leverage knowledge of this regulatory system to diagnose, track, and attenuate disease progression represent a major new research opportunity and challenge in this rapidly growing area of translational medicine.
In the coming years, there is much to be learned about adaptive (and maladaptive) states by examining how the expression of miRNAs is influenced by the genetic architecture of miR genes, clusters, and mirtrons, as well as miRNA polymorphism and polymorphism in their mRNA targets. Clearly, a better understanding of these miRNA regulatory networks, as well as improved therapeutic tools for guiding miRNA expression and their targets toward desired outcomes, will be the subject of many advances in miRNA biology over the coming years.
MicroRNAs: miRRORS of health and disease
MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
Rujuan Dai, S. Ansar Ahmed
Integrating microRNAs into a system biology approach to acute lung injury
Tong Zhou, Joe G.N. Garcia, Wei Zhang
MicroRNAs in idiopathic pulmonary fibrosis
Kusum V. Pandit, Jadranka Milosevic, Naftali Kaminski
Involvement of microRNAs in lung cancer biology and therapy
Xi Liu, Lorenzo F. Sempere, Yongli Guo, Murray Korc, Sakari Kauppinen, Sarah J. Freemantle, Ethan Dmitrovsky
MicroRNA biomarkers in lung cancer: MiRacle or quagMiRe?
Sai Yendamuri, Robert Kratzke
MicroRNAs as therapeutic targets in cancer
S. Patrick Nana-Sinkam, Carlo M. Croce
MicroRNAs in cardiac disease
Gerald W. Dorn II
MicroRNAs in kidney function and disease
Sanjeev Akkina, Bryan N. Becker
MicroRNAs and liver disease
Thomas A. Kerr, Kevin M. Korenblat, Nicholas O. Davidson
Diabetes mellitus, a microRNA-related disease?
Claudiane Guay, Elodie Roggli, Valeria Nesca, Cécile Jacovetti, Romano Regazzi
Subscribe to the miRNA blog
Thank you for subscribing.
Something went wrong.